(S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propionaldehyde

Base Information

Chemical Name:(S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propionaldehyde
CAS No.:855310-81-5
Molecular Formula:C₃₄H₅₉NO₃Si₂
Molecular Weight:586.018
Hs Code.:

(S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propionaldehyde

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Chemical Property of (S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propionaldehyde

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Technology Process of (S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propionaldehyde

There total 10 articles about (S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 855310-80-4
(S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propionitrile

: 855310-81-5
(S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propionaldehyde

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃;
DOI:10.1016/j.tetlet.2005.04.019

Reference yield:

: 855301-94-9
6-phenyl-2,3,5,6,9,10-hexahydro-1H-4-oxa-6a-azacyclopenta[d]naphthalen-3a-ylamine

: 855310-81-5
(S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propionaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1.1: ytterbium triflate; H₂O / tetrahydrofuran / Heating

2.1: ytterbium triflate; H₂O / tetrahydrofuran

2.2: BuLi / tetrahydrofuran / Heating

3.1: 73 percent / BF₃*OEt₂ / diethyl ether; acetonitrile / -50 °C

4.1: 97 percent / imidazole / CH₂Cl₂

5.1: DIBALH / tetrahydrofuran

6.1: imidazole / dimethylformamide

7.1: LDA; HMPA / tetrahydrofuran / -78 °C

8.1: DIBALH / toluene / -78 °C

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; ytterbium trifluoromethanesulfonate; boron trifluoride diethyl etherate; water; diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 2.1: Horner-Emmons olefination;
DOI:10.1016/j.tetlet.2005.04.019

Reference yield:

: 855310-69-9
C₁₇H₂₁NO₂

: 855310-81-5
(S)-2-{(5R,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-1-en-1-yl}-propionaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: ytterbium triflate; H₂O / tetrahydrofuran

1.2: BuLi / tetrahydrofuran / Heating

2.1: 73 percent / BF₃*OEt₂ / diethyl ether; acetonitrile / -50 °C

3.1: 97 percent / imidazole / CH₂Cl₂

4.1: DIBALH / tetrahydrofuran

5.1: imidazole / dimethylformamide

6.1: LDA; HMPA / tetrahydrofuran / -78 °C

7.1: DIBALH / toluene / -78 °C

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; ytterbium trifluoromethanesulfonate; boron trifluoride diethyl etherate; water; diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 1.1: Horner-Emmons olefination;
DOI:10.1016/j.tetlet.2005.04.019