5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid 4-[2-(4-isobutyl-phenyl)-propionyloxymethoxycarbonyl]-phenoxymethyl ester

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Chemical Name:5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid 4-[2-(4-isobutyl-phenyl)-propionyloxymethoxycarbonyl]-phenoxymethyl ester
CAS No.:135922-53-1
Molecular Formula:C₃₅H₃₅NO₁₀
Molecular Weight:629.664
Hs Code.:

5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid 4-[2-(4-isobutyl-phenyl)-propionyloxymethoxycarbonyl]-phenoxymethyl ester

Synonyms:5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid 4-[2-(4-isobutyl-phenyl)-propionyloxymethoxycarbonyl]-phenoxymethyl ester

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Chemical Property of 5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid 4-[2-(4-isobutyl-phenyl)-propionyloxymethoxycarbonyl]-phenoxymethyl ester

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Technology Process of 5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid 4-[2-(4-isobutyl-phenyl)-propionyloxymethoxycarbonyl]-phenoxymethyl ester

There total 6 articles about 5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid 4-[2-(4-isobutyl-phenyl)-propionyloxymethoxycarbonyl]-phenoxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 135922-50-8
chloromethyl 2-(4-isobutylphenyl)propanoate

: 135922-52-0
5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid 4-carboxy-phenoxymethyl ester

: 135922-53-1
5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid 4-[2-(4-isobutyl-phenyl)-propionyloxymethoxycarbonyl]-phenoxymethyl ester

Guidance literature:: With Aliquat 336; In toluene; for 4h; Heating;
DOI:10.1016/0223-5234(91)90108-Y

Reference yield:

: 15687-27-1,58560-75-1
ibuprofen

: 135922-53-1
5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid 4-[2-(4-isobutyl-phenyl)-propionyloxymethoxycarbonyl]-phenoxymethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / Na₂CO₃, Bu₄NHSO₄ / H₂O; CH₂Cl₂ / 0.5 h / 30 °C

2: 55 percent / aliquat 336, 0.1 N soude / toluene / 4 h / Heating

With tetra(n-butyl)ammonium hydrogensulfate; Aliquat 336; sodium carbonate; In dichloromethane; water; toluene;
DOI:10.1016/0223-5234(91)90108-Y

Reference yield:

: 59587-08-5
oxolinic acid sodium salt

: 135922-53-1
5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid 4-[2-(4-isobutyl-phenyl)-propionyloxymethoxycarbonyl]-phenoxymethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 30 percent / aliquat 336 / H₂O; CH₂Cl₂ / 1 h / Ambient temperature

2: 70 percent / Bu₄NBr, KMnO₄ / CH₂Cl₂; H₂O / 3 h / Ambient temperature

3: 55 percent / aliquat 336, 0.1 N soude / toluene / 4 h / Heating

With potassium permanganate; tetrabutylammomium bromide; Aliquat 336; In dichloromethane; water; toluene;
DOI:10.1016/0223-5234(91)90108-Y