6-BENZYLAMINO-9-METHYLPURINE

Base Information

• Chemical Name: 6-BENZYLAMINO-9-METHYLPURINE
• CAS No.: 5440-16-4
• Molecular Formula: C13H13 N5
• Molecular Weight: 239.28
• Hs Code.: 2933990090
• Mol file: 5440-16-4.mol

Synonyms:Adenine,N-benzyl-9-methyl- (7CI,8CI); 6-Benzylamino-9-methylpurine;9-Methyl-N6-benzyladenine; 9-Methylbenzyladenine; N6-Benzyl-9-methyladenine;N6-Benzyl-N9-methyladenine; NSC 15191

Chemical Property of 6-BENZYLAMINO-9-METHYLPURINE

Chemical Property:

• Vapor Pressure: 2.28E-08mmHg at 25°C
• Boiling Point: 452.2°C at 760 mmHg
• Flash Point: 227.3°C
• PSA: 55.63000
• Density: 1.29g/cm³
• LogP: 2.04840

Purity/Quality:

99% ^*data from raw suppliers

N-BENZYL-9-METHYL-9H-PURIN-6-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BENZYLAMINO-9-METHYLPURINE

There total 7 articles about 6-BENZYLAMINO-9-METHYLPURINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

6-chloro-9-methyl-9H-purine (2346-74-9) + benzylamine (100-46-9) → N6-Benzyl-9-methyladenine (5440-16-4)

Guidance literature:

In water; for 12h; Heating;

DOI:10.1016/S0031-9422(82)85006-1

Reference yield: 71.0%

N6-benzyl-N6-methoxy-9-methyladenine hydrobromide (128730-40-5) → N6-Benzyl-9-methyladenine (5440-16-4)

Guidance literature:

Raney Ni W-2; In ethanol; at 50 ℃; for 8h;

DOI:10.1248/cpb.38.652

Reference yield: 30.0%

6-benzyladenine (1214-39-7) + methyl iodide (74-88-4) → N6-Benzyl-9-methyladenine (5440-16-4) + N3-methyl-N6-benzyladenine

Guidance literature:

With sodium hydroxide; In ethanol; at -5 ℃; for 3h; Reflux;

DOI:10.1016/j.molstruc.2008.03.008

upstream raw materials:

6-chloro-9-methyl-9H-purine

benzylamine

N⁶-benzyl-N⁶-methoxy-9-methyladenine hydrobromide

6-chloropurine

Refernces

• 1、 Havlí?ek, Libor,Hanu?, Jan,Vesely, Jaroslav,Leclerc, Sophie,Meijer, Laurent,Shaw, Gordon,Strnad, Miroslav. "Cytokinin-derived cyclin-dependent kinase inhibitors: Synthesis and cdc2 inhibitory activity of olomoucine and related compounds". . p. 408 - 412. Retrieved 2007/10/03.
• 2、 Fujii,Saito,Sakuma,Minami,Inoue. "Purines. xxxviii. A general synthesis of 7,9-dialkyladeninium salts from 9-alkyladenines by regioselective alkylation: Utilization of an N6-alkoxy group as a control synthon". . p. 652 - 660. Retrieved 2007/10/02.