(2S,4S,5S)-1-(4-methoxybenzyloxy)-7-(tert-butyldiphenylsilyloxy)-5-hydroxy-2,4-dimethylheptan-3-one

Base Information

Chemical Name:(2S,4S,5S)-1-(4-methoxybenzyloxy)-7-(tert-butyldiphenylsilyloxy)-5-hydroxy-2,4-dimethylheptan-3-one
CAS No.:1115925-79-5
Molecular Formula:C₃₃H₄₄O₅Si
Molecular Weight:548.795
Hs Code.:

Synonyms:(2S,4S,5S)-1-(4-methoxybenzyloxy)-7-(tert-butyldiphenylsilyloxy)-5-hydroxy-2,4-dimethylheptan-3-one

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Chemical Property of (2S,4S,5S)-1-(4-methoxybenzyloxy)-7-(tert-butyldiphenylsilyloxy)-5-hydroxy-2,4-dimethylheptan-3-one

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Technology Process of (2S,4S,5S)-1-(4-methoxybenzyloxy)-7-(tert-butyldiphenylsilyloxy)-5-hydroxy-2,4-dimethylheptan-3-one

There total 1 articles about (2S,4S,5S)-1-(4-methoxybenzyloxy)-7-(tert-butyldiphenylsilyloxy)-5-hydroxy-2,4-dimethylheptan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 112897-03-7
3-(tert-butyldiphenylsilyloxy)-1-propanal

: 182193-69-7
(S)-1-(p-methoxybenzyloxy)-2-methylpentan-3-one

: 1115925-79-5
(2S,4S,5S)-1-(4-methoxybenzyloxy)-7-(tert-butyldiphenylsilyloxy)-5-hydroxy-2,4-dimethylheptan-3-one

: (2S,4S,5R)-1-(4-methoxybenzyloxy)-7-(tert-butyldiphenylsilyloxy)-5-hydroxy-2,4-dimethylheptan-3-one

Guidance literature:: (S)-1-(p-methoxybenzyloxy)-2-methylpentan-3-one; With dicyclohexylboron chloride; triethylamine; In diethyl ether; at 0 ℃; for 1h; Inert atmosphere;

3-(tert-butyldiphenylsilyloxy)-1-propanal; In diethyl ether; at -78 - -20 ℃; Inert atmosphere;

With dihydrogen peroxide; In methanol; at 0 ℃; for 2h; pH=7; optical yield given as %de; aq. buffer; Inert atmosphere;
DOI:10.1002/adsc.200700589

Reference yield: 65.0%

: 1115925-79-5
(2S,4S,5S)-1-(4-methoxybenzyloxy)-7-(tert-butyldiphenylsilyloxy)-5-hydroxy-2,4-dimethylheptan-3-one

: 1115925-82-0
(2S,3R,4S,5S)-1-(4-methoxybenzyloxy)-7-(tert-butyldiphenylsilyloxy)-2,4-dimethylheptane-3,5-diol

Guidance literature:: With lithium borohydride; tributyl borane; In tetrahydrofuran; at -78 ℃; optical yield given as %de; Inert atmosphere;
DOI:10.1002/adsc.200700589