Dasatinib DiMeric IMpurity

Base Information

• Chemical Name: Dasatinib DiMeric IMpurity
• CAS No.: 910297-61-9
• Molecular Formula: C₃₆H₃₄Cl₂N₁₂O₂S₂
• Molecular Weight: 801.783
• Mol file: 910297-61-9.mol

Synonyms:C₃₆H₃₄Cl₂N₁₂O₂S₂

Chemical Property of Dasatinib DiMeric IMpurity

Chemical Property:

• PKA: 10?+-.0.70(Predicted)
• Density: 1.501±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Very Slightly)

Purity/Quality:

99.90% ^*data from raw suppliers

Dasatinib Dimeric Impurity ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Dasatinib Dimeric Impurity, is an impurity of Dasatinib (D193600), which is a new, oral, small-molecule Tyrosine Kinase Inhibitor (TKI) for the treatment of CML. It is also an Antineoplastic. Dasatinib Dimeric Impurity, is an impurity of Dasatinib (D193600), which is a new, oral, small-molecule Tyrosine Kinase Inhibitor (TKI) for the treatment of CML. It is also an Antineoplastic. It is a COVID19-related research product.

Technology Process of Dasatinib DiMeric IMpurity

There total 1 articles about Dasatinib DiMeric IMpurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.6%

piperazine (110-85-0) + 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide (302964-08-5) → N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin-4-yl)amino)thiazole-5-carboxamide (910297-51-7) + C36H34Cl2N12O2S2 (910297-61-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 0.75h;

upstream raw materials:

piperazine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide