4-(methylsulfonyl)benzyl carbonochloridate

Base Information

• Chemical Name: 4-(methylsulfonyl)benzyl carbonochloridate
• CAS No.: 1173565-24-6
• Molecular Formula: C₉H₉ClO₄S
• Molecular Weight: 248.687
• Mol file: 1173565-24-6.mol

Synonyms:4-(methylsulfonyl)benzyl carbonochloridate

Chemical Property of 4-(methylsulfonyl)benzyl carbonochloridate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(methylsulfonyl)benzyl carbonochloridate

There total 2 articles about 4-(methylsulfonyl)benzyl carbonochloridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(trichloromethyl) carbonate (32315-10-9) + p-methylsulfonylbenzyl alcohol (22821-77-8) → 4-(methylsulfonyl)benzyl carbonochloridate (1173565-24-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 2.5h;

Reference yield:

phosgene (75-44-5) + p-methylsulfonylbenzyl alcohol (22821-77-8) → 4-(methylsulfonyl)benzyl carbonochloridate (1173565-24-6)

Guidance literature:

With potassium carbonate; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2010.10.033

Reference yield: 71.0%

4-(methylsulfonyl)benzyl carbonochloridate (1173565-24-6) + ((3R,4S)-4-((4-(allylamino)piperidin-1-yl)methyl)-3-hydroxy-3-phenylpyrrolidin-1-yl)(cyclopentyl)methanone (934740-48-4) → 4-(methylsulfonyl)benzyl allyl-(1-(((3S,4R)-1-(cyclopentanecarbonyl)-4-hydroxy-4-phenylpyrrolidin-3-yl)methyl)piperidin-4-yl)carbamate (1173564-31-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

upstream raw materials:

bis(trichloromethyl) carbonate

p-methylsulfonylbenzyl alcohol

phosgene

Downstream raw materials:

4-(methylsulfonyl)benzyl allyl-(1-(((3S,4R)-1-(cyclopentanecarbonyl)-4-hydroxy-4-phenylpyrrolidin-3-yl)methyl)piperidin-4-yl)carbamate

C₂₂H₃₂N₂O₆S

Refernces

• 1、 Duan, Maosheng,Peckham, Jennifer,Edelstein, Mark,Ferris, Robert,Kazmierski, Wieslaw M.,Spaltenstein, Andrew,Wheelan, Pat,Xiong, Zhiping. "Discovery of N-benzyl-N′-(4-pipyridinyl)urea CCR5 antagonists as anti-HIV-1 agents (I): Optimization of the amine portion". scheme or table. p. 7397 - 7400. Retrieved 2011/02/23.
• 2、 -. "PYROLLIDINE-BASED COMPOUNDS". Page/Page column 22. . Retrieved 2009/09/05.