Technology Process of 2,4-difluoro-3-n-hexyloxy-5-(2-pyridyl)phenyl boronic acid
There total 8 articles about 2,4-difluoro-3-n-hexyloxy-5-(2-pyridyl)phenyl boronic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(2,4-difluoro-3-n-hexyloxyphenyl)pyridine;
With
n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 2h;
With
Triisopropyl borate;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 14h;
With
hydrogenchloride;
In
tetrahydrofuran; hexane;
for 1h;
pH=Ca. 7;
DOI:10.1039/c4cc01808g
- Guidance literature:
-
In
tetrahydrofuran; hexane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate; sodium iodide / acetonitrile / 14 h / Reflux
2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C
2.2: -78 - 20 °C
3.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; toluene; ethanol / 15 h / Inert atmosphere; Reflux
4.1: n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine / tetrahydrofuran; hexane / 2 h / -78 °C
4.2: 14 h / -78 - 20 °C
With
tetrakis(triphenylphosphine) palladium(0); n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine; potassium carbonate; sodium iodide;
In
tetrahydrofuran; ethanol; hexane; water; toluene; acetonitrile;
