5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanoic acid phenethyl-amide

Base Information

Chemical Name:5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanoic acid phenethyl-amide
CAS No.:402469-34-5
Molecular Formula:C₂₈H₄₃NO₃Si
Molecular Weight:469.74
Hs Code.:

5-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanoic acid phenethyl-amide

Synonyms:5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanoic acid phenethyl-amide

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Chemical Property of 5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanoic acid phenethyl-amide

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Technology Process of 5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanoic acid phenethyl-amide

There total 7 articles about 5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanoic acid phenethyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 64-04-0
phenethylamine

: 402469-33-4
5-[4-(t-butyl-dimethyl-silanyloxy)-3-methoxyphenyl]-3-ethyl-pentanic Acid Ethyl Ester

: 402469-34-5
5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanoic acid phenethyl-amide

Guidance literature:: With trimethylaluminum; In dichloromethane;
DOI:10.1016/S0960-894X(03)00178-1

Reference yield:

: 458-36-6
trans-coniferyl aldehyde

: 402469-34-5
5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanoic acid phenethyl-amide

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / NaH / tetrahydrofuran

2: tetrahydrofuran

3: H₂ / Pd/C / methanol

4: 98 percent / PCC / CH₂Cl₂

5: 58 percent / NaH / tetrahydrofuran

6: 81 percent / H₂ / Pd/C

7: 98 percent / Me₃Al / CH₂Cl₂

With hydrogen; trimethylaluminum; sodium hydride; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; 5: Horner-Worthward-Emmons reaction;
DOI:10.1016/S0960-894X(03)00178-1

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 402469-34-5
5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanoic acid phenethyl-amide

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / NaH / tetrahydrofuran

2: tetrahydrofuran

3: H₂ / Pd/C / methanol

4: 98 percent / PCC / CH₂Cl₂

5: 58 percent / NaH / tetrahydrofuran

6: 81 percent / H₂ / Pd/C

7: 98 percent / Me₃Al / CH₂Cl₂

With hydrogen; trimethylaluminum; sodium hydride; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; 5: Horner-Worthward-Emmons reaction;
DOI:10.1016/S0960-894X(03)00178-1