Technology Process of r-3,cis-6-dibenzyloxy-trans-4,trans-5-(isopropylidenedioxy)cycloheptan-1-one
There total 6 articles about r-3,cis-6-dibenzyloxy-trans-4,trans-5-(isopropylidenedioxy)cycloheptan-1-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
4 A molecular sieve; sodium acetate; pyridinium chlorochromate;
In
dichloromethane;
at 20 ℃;
for 2.5h;
DOI:10.1021/ol027192i
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 94 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran; various solvent(s) / 8 h / Heating
2: 68 percent / osmium tetroxide; N-methylmorpholine N-oxide / tetrahydrofuran; H2O / 2 h / 20 °C
3: 92 percent / p-toluenesulfonic acid monohydrate / 2 h / 20 °C
4: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Heating
5: 94 percent / pyridinium chlorochromate; sodium acetate; molecular sieves 4 Angstroem / CH2Cl2 / 2.5 h / 20 °C
With
osmium(VIII) oxide; 4 A molecular sieve; tetrabutyl ammonium fluoride; sodium acetate; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol027192i
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 94 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran; various solvent(s) / 8 h / Heating
2: 68 percent / osmium tetroxide; N-methylmorpholine N-oxide / tetrahydrofuran; H2O / 2 h / 20 °C
3: 92 percent / p-toluenesulfonic acid monohydrate / 2 h / 20 °C
4: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Heating
5: 94 percent / pyridinium chlorochromate; sodium acetate; molecular sieves 4 Angstroem / CH2Cl2 / 2.5 h / 20 °C
With
osmium(VIII) oxide; 4 A molecular sieve; tetrabutyl ammonium fluoride; sodium acetate; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol027192i
