1-[2-(4-fluorobenzyloxy)-benzoyl]-3-(3-nitrophenyl)thiourea

Base Information

• Chemical Name: 1-[2-(4-fluorobenzyloxy)-benzoyl]-3-(3-nitrophenyl)thiourea
• CAS No.: 1607026-78-7
• Molecular Formula: C₂₁H₁₆FN₃O₄S
• Molecular Weight: 425.44
• Mol file: 1607026-78-7.mol

Synonyms:1-[2-(4-fluorobenzyloxy)-benzoyl]-3-(3-nitrophenyl)thiourea

Chemical Property of 1-[2-(4-fluorobenzyloxy)-benzoyl]-3-(3-nitrophenyl)thiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-[2-(4-fluorobenzyloxy)-benzoyl]-3-(3-nitrophenyl)thiourea

There total 5 articles about 1-[2-(4-fluorobenzyloxy)-benzoyl]-3-(3-nitrophenyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

C15H10FNO2S + 3-nitro-aniline (99-09-2) → 1-[2-(4-fluorobenzyloxy)-benzoyl]-3-(3-nitrophenyl)thiourea (1607026-78-7)

Guidance literature:

In acetonitrile; at 60 - 70 ℃; for 3h;

DOI:10.2174/15701808113109990045

Reference yield:

salicylic acid (69-72-7,25496-36-0,8052-31-1) → 1-[2-(4-fluorobenzyloxy)-benzoyl]-3-(3-nitrophenyl)thiourea (1607026-78-7)

Guidance literature:

Multi-step reaction with 5 steps

1: sulfuric acid

2: potassium carbonate / acetonitrile

3: sodium hydroxide; water / methanol

4: acetonitrile

5: acetonitrile / 3 h / 60 - 70 °C

With sulfuric acid; water; potassium carbonate; sodium hydroxide; In methanol; acetonitrile;

DOI:10.2174/15701808113109990045

Reference yield:

methyl salicylate (119-36-8,8024-54-2) → 1-[2-(4-fluorobenzyloxy)-benzoyl]-3-(3-nitrophenyl)thiourea (1607026-78-7)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile

2: sodium hydroxide; water / methanol

3: acetonitrile

4: acetonitrile / 3 h / 60 - 70 °C

With water; potassium carbonate; sodium hydroxide; In methanol; acetonitrile;

DOI:10.2174/15701808113109990045

upstream raw materials:

3-nitro-aniline

salicylic acid

methyl salicylate

methyl 2-[(4-fluorobenzyl)oxy]benzoate