(E)-3-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)acrylic acid ethyl ester

Base Information

Chemical Name:(E)-3-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)acrylic acid ethyl ester
CAS No.:403706-18-3
Molecular Formula:C₂₇H₃₀O₇
Molecular Weight:466.531
Hs Code.:

Synonyms:(E)-3-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)acrylic acid ethyl ester

Suppliers and Price of (E)-3-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)acrylic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)acrylic acid ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (E)-3-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)acrylic acid ethyl ester

There total 7 articles about (E)-3-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 403706-17-2
3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)benzaldehyde

: 403706-18-3
(E)-3-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)acrylic acid ethyl ester

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In benzene; at 0 ℃; for 0.25h;

3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)benzaldehyde; In benzene; at 0 - 20 ℃; for 1.5h;
DOI:10.1021/jo0611364

Reference yield:

: 22273-56-9
4-hydroxy-5-methoxy-2-methyl-naphthalene

: 403706-18-3
(E)-3-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / CH₂Cl₂ / 24 h / 20 °C

1.2: 67 percent / aq. HCl / 1 h

2.1: 81 percent / NaH / tetrahydrofuran / 20 °C

3.1: NaH / benzene / 0.25 h / 0 °C

3.2: 100 percent / benzene / 1.5 h / 0 - 20 °C

With pyridine; sodium hydride; In tetrahydrofuran; dichloromethane; benzene; 3.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/jo0611364

Reference yield:

: 403706-08-1
3,5-dimethoxy-4-(1-hydroxy-8-methoxy-3-methylnaphthalen-2-yl)benzaldehyde

: 403706-18-3
(E)-3-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 81 percent / NaH / tetrahydrofuran / 20 °C

2.1: NaH / benzene / 0.25 h / 0 °C

2.2: 100 percent / benzene / 1.5 h / 0 - 20 °C

With sodium hydride; In tetrahydrofuran; benzene; 2.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/jo0611364