(+)-(1S)-N-{2-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)-1-methylethyl}acetamide

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Chemical Name:(+)-(1S)-N-{2-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)-1-methylethyl}acetamide
CAS No.:403706-16-1
Molecular Formula:C₂₇H₃₃NO₆
Molecular Weight:467.562
Hs Code.:

Synonyms:(+)-(1S)-N-{2-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)-1-methylethyl}acetamide

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Chemical Property of (+)-(1S)-N-{2-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)-1-methylethyl}acetamide

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Technology Process of (+)-(1S)-N-{2-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)-1-methylethyl}acetamide

There total 12 articles about (+)-(1S)-N-{2-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)-1-methylethyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 75-36-5
acetyl chloride

: 403706-09-2
(+)-(1S)-2-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)-1-methylethylamine

: 403706-16-1
(+)-(1S)-N-{2-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)-1-methylethyl}acetamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jo0611364

Reference yield:

: 403706-13-8
(+)-(2R,3R)-{3-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)-2,3-oxiranyl}methanol

: 403706-16-1
(+)-(1S)-N-{2-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)-1-methylethyl}acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / Et₃N; DMAP / CH₂Cl₂ / 1 h / 0 °C

2: 94 percent / LiAlH₄ / tetrahydrofuran / 2.5 h / 0 - 20 °C

3: 82 percent / PPh₃; DEAD / tetrahydrofuran / 0 - 20 °C

4: 100 percent / aq. MeNH₂ / ethanol / 1 h / Heating

5: 97 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

With dmap; lithium aluminium tetrahydride; triethylamine; triphenylphosphine; methylamine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo0611364

Reference yield:

: 403706-14-9
(+)-(2R,3R)-toluene-4-sulfonic acid 3-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)-2,3-oxiranylmethyl ester

: 403706-16-1
(+)-(1S)-N-{2-(3,5-dimethoxy-4-(8-methoxy-1-methoxymethoxy-3-methylnaphthalen-2-yl)-phenyl)-1-methylethyl}acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / LiAlH₄ / tetrahydrofuran / 2.5 h / 0 - 20 °C

2: 82 percent / PPh₃; DEAD / tetrahydrofuran / 0 - 20 °C

3: 100 percent / aq. MeNH₂ / ethanol / 1 h / Heating

4: 97 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

With lithium aluminium tetrahydride; triethylamine; triphenylphosphine; methylamine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo0611364