(2E,4E)-5-(4-Hydroxy-3-methoxy-phenyl)-penta-2,4-dienoic acid {2-[4-(1H-indol-3-yl)-piperidin-1-yl]-ethyl}-amide

Base Information

Chemical Name:(2E,4E)-5-(4-Hydroxy-3-methoxy-phenyl)-penta-2,4-dienoic acid {2-[4-(1H-indol-3-yl)-piperidin-1-yl]-ethyl}-amide
CAS No.:124956-25-8
Molecular Formula:C₂₇H₃₁N₃O₃
Molecular Weight:445.561
Hs Code.:

Synonyms:(2E,4E)-5-(4-Hydroxy-3-methoxy-phenyl)-penta-2,4-dienoic acid {2-[4-(1H-indol-3-yl)-piperidin-1-yl]-ethyl}-amide

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Chemical Property of (2E,4E)-5-(4-Hydroxy-3-methoxy-phenyl)-penta-2,4-dienoic acid {2-[4-(1H-indol-3-yl)-piperidin-1-yl]-ethyl}-amide

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Technology Process of (2E,4E)-5-(4-Hydroxy-3-methoxy-phenyl)-penta-2,4-dienoic acid {2-[4-(1H-indol-3-yl)-piperidin-1-yl]-ethyl}-amide

There total 8 articles about (2E,4E)-5-(4-Hydroxy-3-methoxy-phenyl)-penta-2,4-dienoic acid {2-[4-(1H-indol-3-yl)-piperidin-1-yl]-ethyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124956-19-0
(2E,4E)-5-[3-Methoxy-4-(2-methoxy-ethoxymethoxy)-phenyl]-penta-2,4-dienoic acid {2-[4-(1H-indol-3-yl)-piperidin-1-yl]-ethyl}-amide

: 124956-25-8
(2E,4E)-5-(4-Hydroxy-3-methoxy-phenyl)-penta-2,4-dienoic acid {2-[4-(1H-indol-3-yl)-piperidin-1-yl]-ethyl}-amide

Guidance literature:: With toluene-4-sulfonic acid; In methanol; Yield given; Heating;
DOI:10.1002/ardp.19963290103

Reference yield:

: 121-33-5,8014-42-4
vanillin

: 124956-25-8
(2E,4E)-5-(4-Hydroxy-3-methoxy-phenyl)-penta-2,4-dienoic acid {2-[4-(1H-indol-3-yl)-piperidin-1-yl]-ethyl}-amide

Guidance literature:: Multi-step reaction with 5 steps

1: iPr₂NEt / 1,2-dichloro-ethane / Heating

2: NaH / tetrahydrofuran

3: NaOH / methanol / Ambient temperature

4: 1) Ph₂P(O)Cl, Et₃N / 1) DMF, -15 to -10 deg C, 2) DMF, r.t.

5: TsOH*H₂O / methanol / Heating

With sodium hydroxide; sodium hydride; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; Diphenylphosphinic chloride; In tetrahydrofuran; methanol; 1,2-dichloro-ethane;
DOI:10.1002/ardp.19963290103

Reference yield:

: 78765-31-8
3-methoxy-4-<2'-(methoxyethoxy)methoxy>-benzaldehyde

: 124956-25-8
(2E,4E)-5-(4-Hydroxy-3-methoxy-phenyl)-penta-2,4-dienoic acid {2-[4-(1H-indol-3-yl)-piperidin-1-yl]-ethyl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran

2: NaOH / methanol / Ambient temperature

3: 1) Ph₂P(O)Cl, Et₃N / 1) DMF, -15 to -10 deg C, 2) DMF, r.t.

4: TsOH*H₂O / methanol / Heating

With sodium hydroxide; sodium hydride; toluene-4-sulfonic acid; triethylamine; Diphenylphosphinic chloride; In tetrahydrofuran; methanol;
DOI:10.1002/ardp.19963290103