(2R,5S)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

Base Information

Chemical Name:(2R,5S)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
CAS No.:1383814-72-9
Molecular Formula:C₁₄H₁₇N₃O₃
Molecular Weight:275.307
Hs Code.:

Synonyms:(2R,5S)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

Suppliers and Price of (2R,5S)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2R,5S)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

Chemical Property:

Boiling Point:543.6±30.0 °C(Predicted)
Density:1.36±0.1 g/cm3(Predicted)

Purity/Quality:: ≥95% ^*data from raw suppliers

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Technology Process of (2R,5S)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

There total 3 articles about (2R,5S)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1383814-70-7,2064219-13-0
(2R,5S)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid

: 1383814-72-9
(2R,5S)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

Guidance literature:: (2R,5S)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid; With triethylamine; isobutyl chloroformate; In dichloromethane; at 0 ℃; for 0.333333h;

With ammonium hydroxide; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1383814-69-4
(2R,5S)-tert-butyl 6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylate

: 1383814-72-9
(2R,5S)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C

2.1: triethylamine; isobutyl chloroformate / dichloromethane / 0.33 h / 0 °C

2.2: 1 h / 20 °C

With triethylamine; trifluoroacetic acid; isobutyl chloroformate; In dichloromethane;

Reference yield:

: C₁₇H₂₆N₂O₃

: 1383814-72-9
(2R,5S)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / acetonitrile / 0.25 h / 0 °C / Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

2.2: 1 h / 0 °C

3.1: sodium dihydrogenphosphate / water

4.1: triethylamine; isobutyl chloroformate / dichloromethane / 0.33 h / 0 °C

4.2: 1 h / 20 °C

With sodium dihydrogenphosphate; triethylamine; trifluoroacetic acid; isobutyl chloroformate; In dichloromethane; water; acetonitrile;