3-(4'-methylbiphenyl-2-yl)-5-(trifluoromethyl)-N-(triphenylmethyl)-1,2,4-triazole

Base Information

• Chemical Name: 3-(4'-methylbiphenyl-2-yl)-5-(trifluoromethyl)-N-(triphenylmethyl)-1,2,4-triazole
• CAS No.: 133910-04-0
• Molecular Formula: C₃₅H₂₆F₃N₃
• Molecular Weight: 545.607
• Mol file: 133910-04-0.mol

Synonyms:3-(4'-methylbiphenyl-2-yl)-5-(trifluoromethyl)-N-(triphenylmethyl)-1,2,4-triazole

Chemical Property of 3-(4'-methylbiphenyl-2-yl)-5-(trifluoromethyl)-N-(triphenylmethyl)-1,2,4-triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4'-methylbiphenyl-2-yl)-5-(trifluoromethyl)-N-(triphenylmethyl)-1,2,4-triazole

There total 1 articles about 3-(4'-methylbiphenyl-2-yl)-5-(trifluoromethyl)-N-(triphenylmethyl)-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

bromo-triphenyl-methane (596-43-0) + 3-(4'-methylbiphenyl-2-yl)-5-(trifluoromethyl)-1,2,4-triazole (124750-65-8) → 3-(4'-methylbiphenyl-2-yl)-5-(trifluoromethyl)-N-(triphenylmethyl)-1,2,4-triazole (133910-04-0)

Guidance literature:

With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 25 ℃; for 18h;

DOI:10.1021/jm00112a031

Reference yield:

3-(4'-methylbiphenyl-2-yl)-5-(trifluoromethyl)-N-(triphenylmethyl)-1,2,4-triazole (133910-04-0) → 3-(4'-Bromomethyl-biphenyl-2-yl)-5-trifluoromethyl-4-trityl-4H-[1,2,4]triazole

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 3h; Heating;

DOI:10.1021/jm00112a031

Reference yield:

3-(4'-methylbiphenyl-2-yl)-5-(trifluoromethyl)-N-(triphenylmethyl)-1,2,4-triazole (133910-04-0) → 2-butyl-4-chloro-5-(hydroxymethyl)-1-<<2'-<5-(trifluoromethyl)-1,2,4-triazol-3-yl>biphenyl-4-yl>methyl>imidazole (124750-23-8)

Guidance literature:

Multi-step reaction with 3 steps

1: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

2: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

3: 10percent HCl / tetrahydrofuran / 4 h / 25 °C

With hydrogenchloride; N-Bromosuccinimide; sodium methylate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane;

DOI:10.1021/jm00112a031

upstream raw materials:

bromo-triphenyl-methane

3-(4'-methylbiphenyl-2-yl)-5-(trifluoromethyl)-1,2,4-triazole

Downstream raw materials:

2-butyl-4-chloro-5-(hydroxymethyl)-1-<<2'-<5-(trifluoromethyl)-1,2,4-triazol-3-yl>biphenyl-4-yl>methyl>imidazole