[2-(2-{2-[2-(2-{[2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carbonyl]-amino}-ethoxy)-ethoxy]-acetylamino}-ethoxy)-ethoxy]-acetic acid

Base Information

• Chemical Name: [2-(2-{2-[2-(2-{[2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carbonyl]-amino}-ethoxy)-ethoxy]-acetylamino}-ethoxy)-ethoxy]-acetic acid
• CAS No.: 874301-27-6
• Molecular Formula: C₃₈H₄₆N₈O₉
• Molecular Weight: 758.831
• Mol file: 874301-27-6.mol

Synonyms:[2-(2-{2-[2-(2-{[2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carbonyl]-amino}-ethoxy)-ethoxy]-acetylamino}-ethoxy)-ethoxy]-acetic acid

Chemical Property of [2-(2-{2-[2-(2-{[2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carbonyl]-amino}-ethoxy)-ethoxy]-acetylamino}-ethoxy)-ethoxy]-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(2-{2-[2-(2-{[2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carbonyl]-amino}-ethoxy)-ethoxy]-acetylamino}-ethoxy)-ethoxy]-acetic acid

There total 13 articles about [2-(2-{2-[2-(2-{[2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carbonyl]-amino}-ethoxy)-ethoxy]-acetylamino}-ethoxy)-ethoxy]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

2'-(4-hydroxyphenyl)-6-(4-methylpiperazin-1-yl)-1H,3'H-2,5'-bibenzoimidazoyl-4-carboxylic acid (874301-24-3) + 8-(9-fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid (166108-71-0,675606-79-8) → [2-(2-{2-[2-(2-{[2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carbonyl]-amino}-ethoxy)-ethoxy]-acetylamino}-ethoxy)-ethoxy]-acetic acid (874301-27-6)

Guidance literature:

Multistep reaction;

DOI:10.1021/jo051836t

Reference yield:

3,4-dinitrobenzoic acid (528-45-0) → [2-(2-{2-[2-(2-{[2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carbonyl]-amino}-ethoxy)-ethoxy]-acetylamino}-ethoxy)-ethoxy]-acetic acid (874301-27-6)

Guidance literature:

Multi-step reaction with 8 steps

1: thionyl chloride / 2 h / 80 °C

2: 7.79 g / pyridine / CH₂Cl₂ / 3.5 h / 0 - 20 °C

3: hydrogen / Pd/C / ethanol / 4 h / 20 °C

4: 3.69 percent / sodium pyrosulfite / ethanol; H₂O / 6 h / Heating

5: 84 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 46 h / -40 - 4 °C

6: 768 mg / sodium pyrosulfite / ethanol; H₂O / 20 h / Heating

7: NaOH / 0.5 h / 70 °C

With pyridine; sodium hydroxide; sodium disulfite; lithium aluminium tetrahydride; thionyl chloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;

DOI:10.1021/jo051836t

Reference yield:

3,4-dinitrobenzoyl chloride (24376-18-9) → [2-(2-{2-[2-(2-{[2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carbonyl]-amino}-ethoxy)-ethoxy]-acetylamino}-ethoxy)-ethoxy]-acetic acid (874301-27-6)

Guidance literature:

Multi-step reaction with 7 steps

1: 7.79 g / pyridine / CH₂Cl₂ / 3.5 h / 0 - 20 °C

2: hydrogen / Pd/C / ethanol / 4 h / 20 °C

3: 3.69 percent / sodium pyrosulfite / ethanol; H₂O / 6 h / Heating

4: 84 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 46 h / -40 - 4 °C

5: 768 mg / sodium pyrosulfite / ethanol; H₂O / 20 h / Heating

6: NaOH / 0.5 h / 70 °C

With pyridine; sodium hydroxide; sodium disulfite; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;

DOI:10.1021/jo051836t

upstream raw materials:

2'-(4-hydroxyphenyl)-6-(4-methylpiperazin-1-yl)-1H,3'H-2,5'-bibenzoimidazoyl-4-carboxylic acid

8-(9-fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid

3-amino-5-chloro-2-nitrobenzoic acid methyl ester

2-(4-hydroxyphenyl)-3H-benzoimidazole-5-carbaldehyde