1α,3β-bis<(tert-butyldimethylsilyl)oxy>-23,24-bisnorchol-5,7-dien-22-ol

Base Information

Chemical Name:1α,3β-bis<(tert-butyldimethylsilyl)oxy>-23,24-bisnorchol-5,7-dien-22-ol
CAS No.:126771-88-8
Molecular Formula:C₃₄H₆₂O₃Si₂
Molecular Weight:575.035
Hs Code.:

Synonyms:1α,3β-bis<(tert-butyldimethylsilyl)oxy>-23,24-bisnorchol-5,7-dien-22-ol

Suppliers and Price of 1α,3β-bis<(tert-butyldimethylsilyl)oxy>-23,24-bisnorchol-5,7-dien-22-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1α,3β-bis<(tert-butyldimethylsilyl)oxy>-23,24-bisnorchol-5,7-dien-22-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1α,3β-bis<(tert-butyldimethylsilyl)oxy>-23,24-bisnorchol-5,7-dien-22-ol

There total 1 articles about 1α,3β-bis<(tert-butyldimethylsilyl)oxy>-23,24-bisnorchol-5,7-dien-22-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20998-18-9
1α,3β-dihydroxy-androst-5-en-17-one

: 126771-88-8
1α,3β-bis<(tert-butyldimethylsilyl)oxy>-23,24-bisnorchol-5,7-dien-22-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 89 percent / imidazole / dimethylformamide / 0.5 h / Ambient temperature

2: 98 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 100 percent / tert-BuOK / tetrahydrofuran / 4 h / Heating

4: 89 percent / BF₃*Et₂O / CH₂Cl₂ / 0.08 h / Ambient temperature

5: 95 percent / H₂ / 5percent Pt/C / ethanol / Ambient temperature

6: 1.) N-bromosuccinimide (NBS), NaHCO₃, 2.) n-Bu₄NBr / 1.) n-hexane, reflux, 1 h, 2.) THF, 0 deg C, 15 min

7: n-Bu₄NF / tetrahydrofuran / 3.5 h / 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; N-Bromosuccinimide; boron trifluoride diethyl etherate; potassium tert-butylate; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; hydrogen; sodium hydrogencarbonate; platinum on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.40.1120

Reference yield:

: 126771-88-8
1α,3β-bis<(tert-butyldimethylsilyl)oxy>-23,24-bisnorchol-5,7-dien-22-ol

: 24,24-difluoroc-1α-hydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 11 steps

1: ethyl acetate

2: 93 percent / DMAP / CH₂Cl₂ / Ambient temperature

3: 86 percent / dimethylsulfoxide / 2 h / 65 °C

4: 90 percent / diisobutylaluminum hydride / toluene; CH₂Cl₂ / 0.42 h / 0 °C

5: 1.) Zn / 1.) THF, reflux, 10 min, 2.) THF, reflux, 10 min

6: 67 percent / diethyl ether / a) 0 deg C, 30 min, b) RT, 2 h

7: DMAP / CH₂Cl₂ / 0.5 h / Ambient temperature

8: Bu₃SnH, 2,2'-azobisisobutyronitrile / toluene / 0.5 h / Heating

9: camphorsulfonic acid / methanol; CHCl₃ / Ambient temperature

10: 98 percent / K₂CO₃ / dimethylsulfoxide / 48 h / 110 - 115 °C

11: 1.) ether, 0 deg C, irradiation, 6 min, 2.) C₂H₅OH, reflux, 1 h

With dmap; 2,2'-azobis(isobutyronitrile); camphor-10-sulfonic acid; tri-n-butyl-tin hydride; diisobutylaluminium hydride; potassium carbonate; zinc; In methanol; diethyl ether; dichloromethane; chloroform; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1248/cpb.44.62

Reference yield:

: 126771-88-8
1α,3β-bis<(tert-butyldimethylsilyl)oxy>-23,24-bisnorchol-5,7-dien-22-ol

: 174201-38-8
24,24-difluoro-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)cholest-6-ene-1α,3β-diol

Guidance literature:: Multi-step reaction with 9 steps

1: ethyl acetate

2: 93 percent / DMAP / CH₂Cl₂ / Ambient temperature

3: 86 percent / dimethylsulfoxide / 2 h / 65 °C

4: 90 percent / diisobutylaluminum hydride / toluene; CH₂Cl₂ / 0.42 h / 0 °C

5: 1.) Zn / 1.) THF, reflux, 10 min, 2.) THF, reflux, 10 min

6: 67 percent / diethyl ether / a) 0 deg C, 30 min, b) RT, 2 h

7: DMAP / CH₂Cl₂ / 0.5 h / Ambient temperature

8: Bu₃SnH, 2,2'-azobisisobutyronitrile / toluene / 0.5 h / Heating

9: camphorsulfonic acid / methanol; CHCl₃ / Ambient temperature

With dmap; 2,2'-azobis(isobutyronitrile); camphor-10-sulfonic acid; tri-n-butyl-tin hydride; diisobutylaluminium hydride; zinc; In methanol; diethyl ether; dichloromethane; chloroform; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1248/cpb.44.62