N-(5-chloro-thiazol-2-yl)-2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionamide

Base Information

Chemical Name:N-(5-chloro-thiazol-2-yl)-2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionamide
CAS No.:1052720-99-6
Molecular Formula:C₂₂H₂₁ClF₃N₃O₂S
Molecular Weight:483.942
Hs Code.:

Synonyms:N-(5-chloro-thiazol-2-yl)-2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionamide

Suppliers and Price of N-(5-chloro-thiazol-2-yl)-2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-chloro-thiazol-2-yl)-2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(5-chloro-thiazol-2-yl)-2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionamide

There total 5 articles about N-(5-chloro-thiazol-2-yl)-2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 41663-73-4
2-amino-5-chlorothiazole

: 1052722-17-4
2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionic acid

: 1052720-99-6
N-(5-chloro-thiazol-2-yl)-2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionamide

Guidance literature:: 2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionic acid; With benzotriazol-1-ol; triethylamine; In dichloromethane; at 0 ℃; for 0.0833333h;

2-amino-5-chlorothiazole; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 12h;

Reference yield:

: 1052722-16-3
2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionic acid ethyl ester

: 1052720-99-6
N-(5-chloro-thiazol-2-yl)-2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide; water / tetrahydrofuran / 18 h / 20 °C

1.2: pH ~ 3 - ~ 4

2.1: benzotriazol-1-ol; triethylamine / dichloromethane / 0.08 h / 0 °C

2.2: 12 h

With lithium hydroxide; water; benzotriazol-1-ol; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 162156-86-7
ethyl 2-(3-aminophenoxy)-2-methylpropanoate

: 1052720-99-6
N-(5-chloro-thiazol-2-yl)-2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / acetonitrile / 72 h / 20 °C

2.1: lithium hydroxide; water / tetrahydrofuran / 18 h / 20 °C

2.2: pH ~ 3 - ~ 4

3.1: benzotriazol-1-ol; triethylamine / dichloromethane / 0.08 h / 0 °C

3.2: 12 h

With lithium hydroxide; water; sodium carbonate; benzotriazol-1-ol; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;