2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionic acid

Base Information

Chemical Name:2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionic acid
CAS No.:1052722-17-4
Molecular Formula:C₁₉H₂₀F₃NO₃
Molecular Weight:367.368
Hs Code.:

Synonyms:2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionic acid

Suppliers and Price of 2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionic acid

There total 4 articles about 2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1052722-16-3
2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionic acid ethyl ester

: 1052722-17-4
2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionic acid

Guidance literature:: 2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionic acid ethyl ester; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 18h;

With hydrogenchloride; water; In ethyl acetate; pH=~ 3 - ~ 4;

Reference yield:

: 1052722-07-2
2-(3-tert-butoxycarbonylamino-phenoxy)-2-methyl-propionic acid ethyl ester

: 1052722-17-4
2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 1.67 h / 0 °C

2.1: sodium carbonate / acetonitrile / 72 h / 20 °C

3.1: lithium hydroxide; water / tetrahydrofuran / 18 h / 20 °C

3.2: pH ~ 3 - ~ 4

With lithium hydroxide; water; sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 19962-06-2
tert-butyl 3-hydroxyphenylcarbamate

: 1052722-17-4
2-methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 - 0.17 h

1.2: 12 h / 70 °C

2.1: trifluoroacetic acid / dichloromethane / 1.67 h / 0 °C

3.1: sodium carbonate / acetonitrile / 72 h / 20 °C

4.1: lithium hydroxide; water / tetrahydrofuran / 18 h / 20 °C

4.2: pH ~ 3 - ~ 4

With lithium hydroxide; water; sodium carbonate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;