(3,5-dichloro-pyridin-4-yl)-[3-(2-hydroxy-ethoxy)-4-methoxy-benzoyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:(3,5-dichloro-pyridin-4-yl)-[3-(2-hydroxy-ethoxy)-4-methoxy-benzoyl]-carbamic acid tert-butyl ester
CAS No.:913985-14-5
Molecular Formula:C₂₀H₂₂Cl₂N₂O₆
Molecular Weight:457.31
Hs Code.:

Synonyms:(3,5-dichloro-pyridin-4-yl)-[3-(2-hydroxy-ethoxy)-4-methoxy-benzoyl]-carbamic acid tert-butyl ester

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Chemical Property of (3,5-dichloro-pyridin-4-yl)-[3-(2-hydroxy-ethoxy)-4-methoxy-benzoyl]-carbamic acid tert-butyl ester

Chemical Property:

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Technology Process of (3,5-dichloro-pyridin-4-yl)-[3-(2-hydroxy-ethoxy)-4-methoxy-benzoyl]-carbamic acid tert-butyl ester

There total 5 articles about (3,5-dichloro-pyridin-4-yl)-[3-(2-hydroxy-ethoxy)-4-methoxy-benzoyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 913985-13-4
{5-[tert-butoxycarbonyl-(3,5-dichloro-pyridin-4-yl)-aminocarbonyl]-2-methoxy-phenoxy}-acetic acid ethyl ester

: 913985-14-5
(3,5-dichloro-pyridin-4-yl)-[3-(2-hydroxy-ethoxy)-4-methoxy-benzoyl]-carbamic acid tert-butyl ester

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 2h;

Reference yield:

: 645-08-9,74309-78-7
Isovanillic acid

: 913985-14-5
(3,5-dichloro-pyridin-4-yl)-[3-(2-hydroxy-ethoxy)-4-methoxy-benzoyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 15 h

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 0 - 20 °C

2.2: 0.5 h / 0 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

4.1: triethylamine / dichloromethane / 0.17 h

4.2: 2 h

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h

5.2: 16 h / 20 °C

6.1: sodium tetrahydroborate / methanol / 2 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; oxalyl dichloride; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 913985-12-3
(3,5-dichloro-pyridin-4-yl)-(3-hydroxy-4-methoxy-benzoyl)-carbamic acid tert-butyl ester

: 913985-14-5
(3,5-dichloro-pyridin-4-yl)-[3-(2-hydroxy-ethoxy)-4-methoxy-benzoyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h

1.2: 16 h / 20 °C

2.1: sodium tetrahydroborate / methanol / 2 h / 0 °C

With sodium tetrahydroborate; potassium carbonate; In methanol; N,N-dimethyl-formamide;