{5-[tert-butoxycarbonyl-(3,5-dichloro-pyridin-4-yl)-aminocarbonyl]-2-methoxy-phenoxy}-acetic acid ethyl ester

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Chemical Name:{5-[tert-butoxycarbonyl-(3,5-dichloro-pyridin-4-yl)-aminocarbonyl]-2-methoxy-phenoxy}-acetic acid ethyl ester
CAS No.:913985-13-4
Molecular Formula:C₂₂H₂₄Cl₂N₂O₇
Molecular Weight:499.348
Hs Code.:

Synonyms:{5-[tert-butoxycarbonyl-(3,5-dichloro-pyridin-4-yl)-aminocarbonyl]-2-methoxy-phenoxy}-acetic acid ethyl ester

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Chemical Property of {5-[tert-butoxycarbonyl-(3,5-dichloro-pyridin-4-yl)-aminocarbonyl]-2-methoxy-phenoxy}-acetic acid ethyl ester

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Technology Process of {5-[tert-butoxycarbonyl-(3,5-dichloro-pyridin-4-yl)-aminocarbonyl]-2-methoxy-phenoxy}-acetic acid ethyl ester

There total 4 articles about {5-[tert-butoxycarbonyl-(3,5-dichloro-pyridin-4-yl)-aminocarbonyl]-2-methoxy-phenoxy}-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 913985-12-3
(3,5-dichloro-pyridin-4-yl)-(3-hydroxy-4-methoxy-benzoyl)-carbamic acid tert-butyl ester

: 105-36-2
ethyl bromoacetate

: 913985-13-4
{5-[tert-butoxycarbonyl-(3,5-dichloro-pyridin-4-yl)-aminocarbonyl]-2-methoxy-phenoxy}-acetic acid ethyl ester

Guidance literature:: (3,5-dichloro-pyridin-4-yl)-(3-hydroxy-4-methoxy-benzoyl)-carbamic acid tert-butyl ester; With potassium carbonate; In N,N-dimethyl-formamide; for 0.166667h;

ethyl bromoacetate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 645-08-9,74309-78-7
Isovanillic acid

: 913985-13-4
{5-[tert-butoxycarbonyl-(3,5-dichloro-pyridin-4-yl)-aminocarbonyl]-2-methoxy-phenoxy}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 15 h

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 0 - 20 °C

2.2: 0.5 h / 0 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

4.1: triethylamine / dichloromethane / 0.17 h

4.2: 2 h

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h

5.2: 16 h / 20 °C

With 1H-imidazole; oxalyl dichloride; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 913985-13-4
{5-[tert-butoxycarbonyl-(3,5-dichloro-pyridin-4-yl)-aminocarbonyl]-2-methoxy-phenoxy}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.17 h

1.2: 2 h

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h

2.2: 16 h / 20 °C

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;