2-({[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid monohydrochloride

Base Information

Chemical Name:2-({[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid monohydrochloride
CAS No.:1372181-04-8
Molecular Formula:C₂₀H₁₈Cl₂F₂N₂O₄*ClH
Molecular Weight:495.738
Hs Code.:

Synonyms:2-({[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid monohydrochloride

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Chemical Property of 2-({[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid monohydrochloride

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Technology Process of 2-({[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid monohydrochloride

There total 14 articles about 2-({[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372187-75-1
2-({[(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid

: 1372181-04-8
2-({[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid monohydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 10 - 35 ℃; for 1h;

Reference yield:

: 1372189-39-3
tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-(hydroxymethyl)-1,4-oxazepane-4-carboxylate

: 1372181-04-8
2-({[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid monohydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / tetrahydrofuran / 2 h / Cooling with ice

2: sodium azide / N,N-dimethyl-formamide / 70 °C

3: triphenylphosphine; water / tetrahydrofuran / 10 - 35 °C

4: N,N-dimethyl-formamide / 80 °C

5: hydrogenchloride / ethyl acetate / 1 h / 10 - 35 °C

With hydrogenchloride; sodium azide; water; triethylamine; triphenylphosphine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; 3: Staudinger Reaction;

Reference yield:

: 1372186-92-9
tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-{[(methylsulfonyl)oxy]methyl}-1,4-oxazepane-4-carboxylate

: 1372181-04-8
2-({[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid monohydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide / 70 °C

2: triphenylphosphine; water / tetrahydrofuran / 10 - 35 °C

3: N,N-dimethyl-formamide / 80 °C

4: hydrogenchloride / ethyl acetate / 1 h / 10 - 35 °C

With hydrogenchloride; sodium azide; water; triphenylphosphine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; 2: Staudinger Reaction;