2-({[(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid

Base Information

Chemical Name:2-({[(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid
CAS No.:1372187-75-1
Molecular Formula:C₂₅H₂₆Cl₂F₂N₂O₆
Molecular Weight:559.394
Hs Code.:

Synonyms:2-({[(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid

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Chemical Property of 2-({[(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid

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Technology Process of 2-({[(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid

There total 13 articles about 2-({[(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18959-30-3
4,5-difluorophthalic anhydride

: 1372186-96-3
tert-butyl (6R,7R)-6-(aminomethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

: 1372187-75-1
2-({[(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid

Guidance literature:: In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

: 1372189-39-3
tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-(hydroxymethyl)-1,4-oxazepane-4-carboxylate

: 1372187-75-1
2-({[(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 2 h / Cooling with ice

2: sodium azide / N,N-dimethyl-formamide / 70 °C

3: triphenylphosphine; water / tetrahydrofuran / 10 - 35 °C

4: N,N-dimethyl-formamide / 80 °C

With sodium azide; water; triethylamine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 3: Staudinger Reaction;

Reference yield:

: 1372186-92-9
tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-{[(methylsulfonyl)oxy]methyl}-1,4-oxazepane-4-carboxylate

: 1372187-75-1
2-({[(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}carbamoyl)-4,5-difluorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / N,N-dimethyl-formamide / 70 °C

2: triphenylphosphine; water / tetrahydrofuran / 10 - 35 °C

3: N,N-dimethyl-formamide / 80 °C

With sodium azide; water; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Staudinger Reaction;