1-(5-(4-chlorophenyl)-1,3,4-thiadiazol-2-ylsulfonyl)-4-methylpiperazine

Base Information

Chemical Name:1-(5-(4-chlorophenyl)-1,3,4-thiadiazol-2-ylsulfonyl)-4-methylpiperazine
CAS No.:1257421-80-9
Molecular Formula:C₁₃H₁₅ClN₄O₂S₂
Molecular Weight:358.873
Hs Code.:

Synonyms:1-(5-(4-chlorophenyl)-1,3,4-thiadiazol-2-ylsulfonyl)-4-methylpiperazine

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Chemical Property of 1-(5-(4-chlorophenyl)-1,3,4-thiadiazol-2-ylsulfonyl)-4-methylpiperazine

Chemical Property:

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Technology Process of 1-(5-(4-chlorophenyl)-1,3,4-thiadiazol-2-ylsulfonyl)-4-methylpiperazine

There total 6 articles about 1-(5-(4-chlorophenyl)-1,3,4-thiadiazol-2-ylsulfonyl)-4-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.4%

: 109-01-3
1-methyl-piperazine

: 328527-98-6
5-(4-chlorophenyl)-1,3,4-thiadiazole-2-sulfonyl chloride

: 1257421-80-9
1-(5-(4-chlorophenyl)-1,3,4-thiadiazol-2-ylsulfonyl)-4-methylpiperazine

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 6h;
DOI:10.3390/molecules15129046

Reference yield:

: 1126-46-1
Methyl 4-chlorobenzoate

: 1257421-80-9
1-(5-(4-chlorophenyl)-1,3,4-thiadiazol-2-ylsulfonyl)-4-methylpiperazine

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine hydrate / ethanol / 8 h / Reflux

2: potassium hydroxide / ethanol / 20 °C

3: sulfuric acid / -2 - 0 °C

4: hydrogenchloride; water; chlorine / 1,2-dichloro-ethane / -2 °C

5: triethylamine / acetonitrile / 6 h / 20 °C

With hydrogenchloride; sulfuric acid; water; chlorine; hydrazine hydrate; triethylamine; potassium hydroxide; In ethanol; 1,2-dichloro-ethane; acetonitrile;
DOI:10.3390/molecules15129046

Reference yield:

: 38539-88-7
potassium p-chlorobenzoylhydrazinodithioformate

: 1257421-80-9
1-(5-(4-chlorophenyl)-1,3,4-thiadiazol-2-ylsulfonyl)-4-methylpiperazine

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / -2 - 0 °C

2: hydrogenchloride; water; chlorine / 1,2-dichloro-ethane / -2 °C

3: triethylamine / acetonitrile / 6 h / 20 °C

With hydrogenchloride; sulfuric acid; water; chlorine; triethylamine; In 1,2-dichloro-ethane; acetonitrile;
DOI:10.3390/molecules15129046