328527-98-6

Upstream product

• 63857-85-2 2-mercapto-5-(4'-chlorophenyl)-1,3,4-thiadiazole 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 38539-88-7 potassium p-chlorobenzoylhydrazinodithioformate 
• 74-11-3 para-chlorobenzoic acid 
• 536-40-3 4-chlorobenzoic acid hydrazide 

Downstream Products

• 835621-88-0 N-{2-[5-(4-chlorophenyl)-1,3,4-thiadiazole-2-sulfonylamino]-ethyl}-glycine ethyl ester 
• 1257421-76-3 1-(5-(4-chlorophenyl)-1,3,4-thiadiazol-2-ylsulfonyl)piperidine 
• 1257421-80-9 1-(5-(4-chlorophenyl)-1,3,4-thiadiazol-2-ylsulfonyl)-4-methylpiperazine 
• 1257421-81-0 diisopropyl (2-(4-chlorophenyl)-1,3,4-thiadiazole-5-sulfonamido)(2-fluorophenyl)methylphosphonate 
• 1257421-83-2 C₂₃H₁₅Cl₂N₅O₄S₄ 
• 1257421-77-4 5-(4-chlorophenyl)-N-(p-tolyl)-1,3,4-thiadiazole-2-sulfonamide 
• 1257421-82-1 N,5-bis(4-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide 
• 1257421-84-3 N-(3-chlorophenyl)-5-(4-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide 
• 1257421-78-5 diethyl (2-(4-chlorophenyl)-1,3,4-thiadiazole-5-sulfonamido)(2-fluorophenyl)methylphosphonate 

Relevant academic research and scientific papers

Synthesis and antiviral activity of 5-(4-chlorophenyl)-1,3,4- thiadiazole sulfonamides

Starting from 4-chlorobenzoic acid, 10 new 5-(4-chlorophenyl)-N- substituted-N- 1,3,4-thiadiazole-2-sulfonamide derivatives were synthesized in six-steps. Esterification of 4-chlorobenzoic acid with methanol and subsequent hydrazination, salt formation and cyclization afforded 5-(4-chlorophen-yl)-1,3, 4-thiadiazole-2-thiol (5). Conversion of this intermediate into sulfonyl chloride 6, followed by nucleophilic attack of the amines gave the title sulfonamides 7a-7j whose structures were confirmed by NMR, IR and elemental analysis. The bioassay tests showed that compounds 7b and 7i possessed certain antitobacco mosaic virus activity.

Synthesis of some N1-phenyl-N3-[2-aryl/aryloxymethyl-1,3,4-oxa(thia)diazol-2-yl]sulphonyl ureas as potential pesticides

N1-Phenyl-N3-aryl/aryloxymethyl[1,3,4-oxa(thia)diazol-2-yl]sulphonyl ureas (4 and 7) were conveniently prepared from 2-aryl/aryloxymethyl-1,3,4-oxa(thia)diazol-2-sulphonamide (3 and 6) and phenyl isothiocyanate. Sulphonamides were sy