C₁₁H₁₄F₂O

Base Information

• Chemical Name: C₁₁H₁₄F₂O
• CAS No.: 1340434-94-7
• Molecular Formula: C₁₁H₁₄F₂O
• Molecular Weight: 200.228
• Mol file: 1340434-94-7.mol

Synonyms:C₁₁H₁₄F₂O

Chemical Property of C₁₁H₁₄F₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₁H₁₄F₂O

There total 1 articles about C₁₁H₁₄F₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.9%

n-butyl magnesium bromide (693-03-8) + 2,6-difluorobenzaldehyde (437-81-0) → C11H14F2O (1340434-94-7)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c2cc18147a

Reference yield: 88.2%

C11H14F2O (1340434-94-7) → C11H12F2O (1372802-68-0)

Guidance literature:

C₁₁H₁₄F₂O; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -80 ℃; for 0.333333h;

With triethylamine; In dichloromethane; at -80 ℃; for 0.5h;

DOI:10.1039/c2cc18147a

Reference yield:

C11H14F2O (1340434-94-7) → C15H22F2 (1372802-67-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.33 h / -80 °C

1.2: 0.5 h / -80 °C

2.1: tetrahydrofuran / 0 - 25 °C

3.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 20 °C

4.1: palladium on activated charcoal; hydrogen / methanol

With sodium tetrahydroborate; oxalyl dichloride; palladium on activated charcoal; hydrogen; dimethyl sulfoxide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1039/c2cc18147a

upstream raw materials:

n-butyl magnesium bromide

2,6-difluorobenzaldehyde

Downstream raw materials:

C₁₅H₂₂F₂

C₁₁H₁₂F₂O

C₁₅H₂₂F₂O

C₁₅H₂₀F₂