(R)-3-[((S)-Methylcarbamoyl-phenyl-methyl)-carbamoyl]-dodecanoic acid tert-butyl ester

Base Information

Chemical Name:(R)-3-[((S)-Methylcarbamoyl-phenyl-methyl)-carbamoyl]-dodecanoic acid tert-butyl ester
CAS No.:334756-91-1
Molecular Formula:C₂₆H₄₂N₂O₄
Molecular Weight:446.63
Hs Code.:

Synonyms:(R)-3-[((S)-Methylcarbamoyl-phenyl-methyl)-carbamoyl]-dodecanoic acid tert-butyl ester

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Chemical Property of (R)-3-[((S)-Methylcarbamoyl-phenyl-methyl)-carbamoyl]-dodecanoic acid tert-butyl ester

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Technology Process of (R)-3-[((S)-Methylcarbamoyl-phenyl-methyl)-carbamoyl]-dodecanoic acid tert-butyl ester

There total 5 articles about (R)-3-[((S)-Methylcarbamoyl-phenyl-methyl)-carbamoyl]-dodecanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 334756-91-1
(R)-3-[((S)-Methylcarbamoyl-phenyl-methyl)-carbamoyl]-dodecanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: LDA / tetrahydrofuran; hexane / -78 - 20 °C

2: 1.) aq. H₂O₂, LiOH, 2.) NaNO₂ / 1.) THF, RT, 1.5 h, 2.) THF, 30 min

3: HOBT, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / Ambient temperature

With lithium hydroxide; dihydrogen peroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; sodium nitrite; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm970404a

Reference yield:

: 17746-05-3
undecanoyl chloride

: 334756-91-1
(R)-3-[((S)-Methylcarbamoyl-phenyl-methyl)-carbamoyl]-dodecanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 25 min, 2.) THF, hexane, from -78 deg C to RT

2: LDA / tetrahydrofuran; hexane / -78 - 20 °C

3: 1.) aq. H₂O₂, LiOH, 2.) NaNO₂ / 1.) THF, RT, 1.5 h, 2.) THF, 30 min

4: HOBT, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / Ambient temperature

With lithium hydroxide; n-butyllithium; dihydrogen peroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; sodium nitrite; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm970404a

Reference yield:

: 245652-05-5
R-3-[1-((1S)-4-benzyl-2-oxo-oxazolidin-3-yl)-methanoyl]-dadecanoic acid tert-butyl ester

: 334756-91-1
(R)-3-[((S)-Methylcarbamoyl-phenyl-methyl)-carbamoyl]-dodecanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) aq. H₂O₂, LiOH, 2.) NaNO₂ / 1.) THF, RT, 1.5 h, 2.) THF, 30 min

2: HOBT, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / Ambient temperature

With lithium hydroxide; dihydrogen peroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium nitrite; In N,N-dimethyl-formamide;
DOI:10.1021/jm970404a