methyl 1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole-6-carboxylate

Base Information

Chemical Name:methyl 1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole-6-carboxylate
CAS No.:1613504-95-2
Molecular Formula:C₂₁H₁₉F₃N₂O₃
Molecular Weight:404.389
Hs Code.:

Synonyms:methyl 1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole-6-carboxylate

Suppliers and Price of methyl 1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole-6-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole-6-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole-6-carboxylate

There total 4 articles about methyl 1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613504-87-2
methyl 5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-6-carboxylate

: 1423-27-4
2-(trifluoromethyl)phenylboronic acid

: 1613504-95-2
methyl 1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole-6-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; at 120 ℃; Microwave irradiation;
DOI:10.1021/jm401986p

Reference yield:

: 18595-18-1
3-amino-4-methyl benzoic acid methyl ester

: 1613504-95-2
methyl 1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C / Cooling with ice

2.1: boron trifluoride diethyl etherate; tert.-butylnitrite / dichloromethane / -78 - 20 °C / Inert atmosphere

2.2: 20 °C

3.1: toluene-4-sulfonic acid / chloroform / 20 - 50 °C

4.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 120 °C / Microwave irradiation

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; boron trifluoride diethyl etherate; caesium carbonate; toluene-4-sulfonic acid; In 1,4-dioxane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; 4.1: |Suzuki Coupling;
DOI:10.1021/jm401986p

Reference yield:

: 474330-54-6
5-amino-2-bromo-4-methylbenzoic acid methyl ester

: 1613504-95-2
methyl 1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazole-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate; tert.-butylnitrite / dichloromethane / -78 - 20 °C / Inert atmosphere

1.2: 20 °C

2.1: toluene-4-sulfonic acid / chloroform / 20 - 50 °C

3.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 120 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; boron trifluoride diethyl etherate; caesium carbonate; toluene-4-sulfonic acid; In 1,4-dioxane; dichloromethane; chloroform; water; 3.1: |Suzuki Coupling;
DOI:10.1021/jm401986p