3,N*1*-Dimethyl-benzene-1,2-diamine

Base Information

• Chemical Name: 3,N*1*-Dimethyl-benzene-1,2-diamine
• CAS No.: 73902-64-4
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.197
• Mol file: 73902-64-4.mol

Synonyms:N¹,3-dimethylbenzene-1,2-diamine

Chemical Property of 3,N*1*-Dimethyl-benzene-1,2-diamine

Chemical Property:

• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

N1,3-Dimethylbenzene-1,2-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,N*1*-Dimethyl-benzene-1,2-diamine

There total 7 articles about 3,N*1*-Dimethyl-benzene-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-methyl-2-nitro-N-methylaniline (70254-75-0) → N1,3-dimethylbenzene-1,2-diamine (73902-64-4)

Guidance literature:

3-methyl-2-nitro-N-methylaniline; With ethanol; tin(ll) chloride; at 75 ℃; for 23h;

With sodium hydroxide; In water; pH=14;

DOI:10.1021/acs.jmedchem.0c02094

Reference yield: 71.0%

tetrabutylammonium o-tolylsulfamate + O-(4-methoxybenzoyl)-N-methylhydroxylammonium trifluoromethanesulfonate → N1,3-dimethylbenzene-1,2-diamine (73902-64-4) + 3-methyl-4-amino-N-methyl aniline

Guidance literature:

tetrabutylammonium o-tolylsulfamate; O-(4-methoxybenzoyl)-N-methylhydroxylammonium trifluoromethanesulfonate; With iron(II) bromide; at 30 ℃; for 4h;

With hydrogenchloride; In methanol; at 20 ℃; for 1h;

DOI:10.1021/jacs.1c05531

Reference yield:

3-methyl-2-nitroaniline (601-87-6) → N1,3-dimethylbenzene-1,2-diamine (73902-64-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / conc. H₂SO₄ / acetic acid / 0.67 h / 90 °C

2: 1.) 85percent KOH, 2.) H₂O / 1.) DMSO, 0 deg C, 2 h, 2.) DMSO, 100 deg C, 30 min

3: H₂, boric acid / 10percent Pd/C / acetic acid / 750.06 Torr / Ambient temperature

With potassium hydroxide; sulfuric acid; water; hydrogen; boric acid; palladium on activated charcoal; In acetic acid;

upstream raw materials:

3-methyl-2-nitro-N-methylaniline

3-methyl-2-nitroaniline

N-(3-methyl-2-nitrophenyl)acetamide

o-toluidine

Downstream raw materials:

1,4-dimethyl-1H-benzo[d]imidazole

Refernces

• 1、 Dong, Yaxi,Breit, Bernhard. "Cu-Catalyzed C-H Allylation of Benzimidazoles with Allenes". supporting information. p. 6765 - 6769. Retrieved 2021/09/11.
• 2、 -. "ANTIBIOTIC COMPOUNDS". Page/Page column 120; 121. . Retrieved 2018/03/25.