3-methyl-2-nitro-N-methylaniline

Base Information

• Chemical Name: 3-methyl-2-nitro-N-methylaniline
• CAS No.: 70254-75-0
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Mol file: 70254-75-0.mol

Synonyms:3-methyl-2-nitro-N-methylaniline

Chemical Property of 3-methyl-2-nitro-N-methylaniline

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Methyl-(3-methyl-2-nitro-phenyl)-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methyl-2-nitro-N-methylaniline

There total 8 articles about 3-methyl-2-nitro-N-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-fluoro-3-methyl-2-nitro-benzene (3013-27-2) + methylamine (74-89-5) → 3-methyl-2-nitro-N-methylaniline (70254-75-0)

Guidance literature:

In ethanol; water; for 8h; Reflux;

Reference yield: 71.0%

dimethyl sulfate (77-78-1) + 3-methyl-2-nitrotrifluoroacetanilide (183492-45-7) → 3-methyl-2-nitro-N-methylaniline (70254-75-0)

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In toluene; Ambient temperature;

DOI:10.1080/00397919608003827

Reference yield: 36.0%

3-methyl-2-nitroaniline (601-87-6) + methyl iodide (74-88-4) → 3-methyl-2-nitro-N-methylaniline (70254-75-0)

Guidance literature:

3-methyl-2-nitroaniline; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 21h;

DOI:10.1021/acs.jmedchem.0c02094

upstream raw materials:

N-(3-methyl-2-nitrophenyl)acetamide

methyl iodide

3-chloro-2-nitrotoluene

methylamine

Downstream raw materials:

1,4-dimethyl-1H-benzo[d]imidazole

N¹,3-dimethylbenzene-1,2-diamine

Refernces

• 1、 Pallesen, Jakob S.,Narayanan, Dilip,Tran, Kim T.,Solbak, Sara M. ?.,Marseglia, Giuseppe,S?rensen, Louis M. E.,H?j, Lars J.,Munafò, Federico,Carmona, Rosa M. C.,Garcia, Anthony D.,Desu, Haritha L.,Brambilla, Roberta,Johansen, Tommy N.,Popowicz, Grzegorz M.,Sattler, Michael,Gajhede, Michael,Bach, Anders. "Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds". . p. 4623 - 4661. Retrieved 2021/05/07.
• 2、 -. "ANTIBIOTIC COMPOUNDS". Page/Page column 120; 121. . Retrieved 2018/03/25.