2-[N-methyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide

Base Information

Chemical Name:2-[N-methyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide
CAS No.:350603-03-1
Molecular Formula:C₂₄H₂₄N₄O₃
Molecular Weight:416.48
Hs Code.:

Synonyms:2-[N-methyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide

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Chemical Property of 2-[N-methyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide

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Technology Process of 2-[N-methyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide

There total 6 articles about 2-[N-methyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 52522-99-3
2,4-dimethoxy-5-iodopyrimidine

: 350602-99-2
2-(N-methyl-N-prop-2'-ynyl)amino-N'-p-tolylbenzamide

: 350603-03-1
2-[N-methyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; at 20 ℃; for 16h;
DOI:10.1016/S0040-4039(01)00312-4

Reference yield:

: 137105-06-7
methyl 2-(N-prop-2'-ynyl)aminobenzoate

: 350603-03-1
2-[N-methyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / K₂CO₃ / dimethylformamide / 24 h / 60 °C

2: 90 percent / aq. KOH / methanol / 24 h / 20 °C

3: SOCl₂; pyridine / benzene / 1.5 h / 55 °C

4: 1.8 g / benzene / 16 h / 20 °C

5: 79 percent / (Ph₃P)2PdCl₂; CuI; Et₃N / acetonitrile / 16 h / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; copper(l) iodide; thionyl chloride; potassium carbonate; triethylamine; In methanol; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1016/S0040-4020(01)00637-8

Reference yield:

: 134-20-3
2-carbomethoxyaniline

: 350603-03-1
2-[N-methyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / K₂CO₃ / dimethylformamide / 48 h / 80 °C

2: 72 percent / K₂CO₃ / dimethylformamide / 24 h / 60 °C

3: 90 percent / aq. KOH / methanol / 24 h / 20 °C

4: SOCl₂; pyridine / benzene / 1.5 h / 55 °C

5: 1.8 g / benzene / 16 h / 20 °C

6: 79 percent / (Ph₃P)2PdCl₂; CuI; Et₃N / acetonitrile / 16 h / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; copper(l) iodide; thionyl chloride; potassium carbonate; triethylamine; In methanol; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1016/S0040-4020(01)00637-8