4-methyl-5-oxo-2,5-dihydro-2-furanyl salicylate

Base Information

• Chemical Name: 4-methyl-5-oxo-2,5-dihydro-2-furanyl salicylate
• CAS No.: 1353054-35-9
• Molecular Formula: C₁₂H₁₀O₅
• Molecular Weight: 234.208
• Mol file: 1353054-35-9.mol

Synonyms:4-methyl-5-oxo-2,5-dihydro-2-furanyl salicylate

Chemical Property of 4-methyl-5-oxo-2,5-dihydro-2-furanyl salicylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-5-oxo-2,5-dihydro-2-furanyl salicylate

There total 3 articles about 4-methyl-5-oxo-2,5-dihydro-2-furanyl salicylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-bromo-4-methyl-2H-furan-5-one (59488-94-7) + sodium salicylate (54-21-7) → 4-methyl-5-oxo-2,5-dihydro-2-furanyl salicylate (1353054-35-9)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.bmcl.2013.07.004

Reference yield: 41.6%

2-chloro-4-methyl-2H-furan-5-one (66510-25-6) + sodium salicylate (54-21-7) → 4-methyl-5-oxo-2,5-dihydro-2-furanyl salicylate (1353054-35-9)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 65h; Inert atmosphere;

DOI:10.1016/j.bmc.2011.10.057

Reference yield:

3-methyl-5H-furan-2-one (22122-36-7) → 4-methyl-5-oxo-2,5-dihydro-2-furanyl salicylate (1353054-35-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / dichloromethane / 3 h / Reflux; Dean-Stark

2: N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; dibenzoyl peroxide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.07.004

upstream raw materials:

2-chloro-4-methyl-2H-furan-5-one

sodium salicylate

2-bromo-4-methyl-2H-furan-5-one

3-methyl-5H-furan-2-one