5-(1-hydroxy-1-methylethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Base Information

Chemical Name:5-(1-hydroxy-1-methylethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide
CAS No.:1285514-68-2
Molecular Formula:C₂₂H₂₂N₂O₃
Molecular Weight:362.428
Hs Code.:

Synonyms:5-(1-hydroxy-1-methylethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

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Chemical Property of 5-(1-hydroxy-1-methylethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

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Technology Process of 5-(1-hydroxy-1-methylethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

There total 3 articles about 5-(1-hydroxy-1-methylethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1285514-60-4
5-acetyl-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

: 75-16-1
methylmagnesium bromide

: 1285514-68-2
5-(1-hydroxy-1-methylethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Guidance literature:: 5-acetyl-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide; methylmagnesium bromide; In tetrahydrofuran; at 0 ℃; for 18.75h;

With sulfuric acid; In tetrahydrofuran; for 0.05h;

With sodium hydrogencarbonate; In tetrahydrofuran; ethyl acetate; pH=9;

Reference yield:

: 462-08-8
pyridin-3-ylamine

: 1285514-68-2
5-(1-hydroxy-1-methylethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h

2.1: tetrahydrofuran / 18.75 h / 0 °C

2.2: 0.05 h

2.3: pH 9

With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 201663-18-5
5-acetyl-2-(benzyloxy)benzoic acid

: 1285514-68-2
5-(1-hydroxy-1-methylethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h

2.1: tetrahydrofuran / 18.75 h / 0 °C

2.2: 0.05 h

2.3: pH 9

With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;