4,7-bis(tert-butoxycarbonylmethyl)-1-(4-nitro-benzyl)-1,4,7-triazacyclononane

Base Information

• Chemical Name: 4,7-bis(tert-butoxycarbonylmethyl)-1-(4-nitro-benzyl)-1,4,7-triazacyclononane
• CAS No.: 1374994-87-2
• Molecular Formula: C₂₅H₄₀N₄O₆
• Molecular Weight: 492.616
• Mol file: 1374994-87-2.mol

Synonyms:4,7-bis(tert-butoxycarbonylmethyl)-1-(4-nitro-benzyl)-1,4,7-triazacyclononane

Chemical Property of 4,7-bis(tert-butoxycarbonylmethyl)-1-(4-nitro-benzyl)-1,4,7-triazacyclononane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,7-bis(tert-butoxycarbonylmethyl)-1-(4-nitro-benzyl)-1,4,7-triazacyclononane

There total 1 articles about 4,7-bis(tert-butoxycarbonylmethyl)-1-(4-nitro-benzyl)-1,4,7-triazacyclononane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

1,4-bis(tert-butoxycarbonylmethyl)-1,4,7-triazacyclononane (174137-97-4) + 1-bromomethyl-4-nitro-benzene (100-11-8) → 4,7-bis(tert-butoxycarbonylmethyl)-1-(4-nitro-benzyl)-1,4,7-triazacyclononane (1374994-87-2)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 20h;

DOI:10.1016/j.bmc.2012.07.050

Reference yield:

4,7-bis(tert-butoxycarbonylmethyl)-1-(4-nitro-benzyl)-1,4,7-triazacyclononane (1374994-87-2) → 4,7-bis(carboxymethyl)-1-(4-nitro-benzyl)-1,4,7-triazacyclononane hydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 24h;

DOI:10.1016/j.bmc.2012.07.050

Reference yield:

4,7-bis(tert-butoxycarbonylmethyl)-1-(4-nitro-benzyl)-1,4,7-triazacyclononane (1374994-87-2) → 2-{4-(carboxymethyl)-7-[(4-nitrophenyl)methyl]-1,4,7-triazacyclononan-1-yl}acetic acid

Guidance literature:

With trifluoroacetic acid; for 5h;

upstream raw materials:

1,4-bis(tert-butoxycarbonylmethyl)-1,4,7-triazacyclononane

1-bromomethyl-4-nitro-benzene

Downstream raw materials:

4,7-bis(carboxymethyl)-1-(4-amino-benzyl)-1,4,7-triazacyclononane

(2,2′-(7-(4-isothiocyanatobenzyl)-1,4,7-triazonane-1,4-diyl)diacetic acid)

C₄₅H₆₅N₁₃O₁₂S