{allyl-[5-[4-(3-but-3-enyloxyphenyl)pyrimidin-2-ylamino]-2-(2-pyrrolidin-1-ylethoxy)benzyl]amino}acetonitrile

Base Information

Chemical Name:{allyl-[5-[4-(3-but-3-enyloxyphenyl)pyrimidin-2-ylamino]-2-(2-pyrrolidin-1-ylethoxy)benzyl]amino}acetonitrile
CAS No.:1354567-71-7
Molecular Formula:C₃₂H₃₈N₆O₂
Molecular Weight:538.693
Hs Code.:

Synonyms:{allyl-[5-[4-(3-but-3-enyloxyphenyl)pyrimidin-2-ylamino]-2-(2-pyrrolidin-1-ylethoxy)benzyl]amino}acetonitrile

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Chemical Property of {allyl-[5-[4-(3-but-3-enyloxyphenyl)pyrimidin-2-ylamino]-2-(2-pyrrolidin-1-ylethoxy)benzyl]amino}acetonitrile

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Technology Process of {allyl-[5-[4-(3-but-3-enyloxyphenyl)pyrimidin-2-ylamino]-2-(2-pyrrolidin-1-ylethoxy)benzyl]amino}acetonitrile

There total 8 articles about {allyl-[5-[4-(3-but-3-enyloxyphenyl)pyrimidin-2-ylamino]-2-(2-pyrrolidin-1-ylethoxy)benzyl]amino}acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 937271-45-9
4-(3-(but-3-en-1-yloxy)phenyl)-2-chloropyrimidine

: 1354567-43-3
{allyl-[5-amino-2-(2-pyrrolidin-1-ylethoxy)benzyl]amino}acetonitrile

: 1354567-71-7
{allyl-[5-[4-(3-but-3-enyloxyphenyl)pyrimidin-2-ylamino]-2-(2-pyrrolidin-1-ylethoxy)benzyl]amino}acetonitrile

Guidance literature:: With hydrogenchloride; In water; butan-1-ol; at 90 - 100 ℃;
DOI:10.1021/jm201112g

Reference yield:

: 110837-53-1
2-(2-chloroethoxy)-5-nitrobenzaldehyde

: 1354567-71-7
{allyl-[5-[4-(3-but-3-enyloxyphenyl)pyrimidin-2-ylamino]-2-(2-pyrrolidin-1-ylethoxy)benzyl]amino}acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 70 °C

3: N,N-dimethyl acetamide / 90 °C

4: iron; ammonium chloride / ethanol; water / Reflux

5: hydrogenchloride / water; butan-1-ol / 90 - 100 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; iron; potassium carbonate; ammonium chloride; In ethanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/jm201112g

Reference yield:

: 937271-43-7
3-(2-chloropyrimidine-4-yl)phenol

: 1354567-71-7
{allyl-[5-[4-(3-but-3-enyloxyphenyl)pyrimidin-2-ylamino]-2-(2-pyrrolidin-1-ylethoxy)benzyl]amino}acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 40 °C

2: hydrogenchloride / water; butan-1-ol / 90 - 100 °C

With hydrogenchloride; caesium carbonate; In water; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/jm201112g