4-(3-(But-3-en-1-yloxy)phenyl)-2-chloropyrimidine

Base Information

Chemical Name:4-(3-(But-3-en-1-yloxy)phenyl)-2-chloropyrimidine
CAS No.:937271-45-9
Molecular Formula:C₁₄H₁₃ClN₂O
Molecular Weight:260.723
Hs Code.:
DSSTox Substance ID:DTXSID001239105

Synonyms:4-(3-(But-3-en-1-yloxy)phenyl)-2-chloropyrimidine;937271-45-9;1140503-30-5;4-(3-but-3-enoxyphenyl)-2-chloropyrimidine;4-[3-(but-3-en-1-yloxy)phenyl]-2-chloropyrimidine;SCHEMBL823963;DTXSID001239105;MFCD28506209;SB18667;4-[3-(3-Buten-1-yloxy)phenyl]-2-chloropyrimidine

Suppliers and Price of 4-(3-(But-3-en-1-yloxy)phenyl)-2-chloropyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Alichem
4-(3-(But-3-en-1-yloxy)phenyl)-2-chloropyrimidine
5g
$ 1049.40

Alichem
4-(3-(But-3-en-1-yloxy)phenyl)-2-chloropyrimidine
1g
$ 330.00

Total 11 raw suppliers

Chemical Property of 4-(3-(But-3-en-1-yloxy)phenyl)-2-chloropyrimidine

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:260.0716407
Heavy Atom Count:18
Complexity:262

Purity/Quality:

97% ^*data from raw suppliers

4-(3-(But-3-en-1-yloxy)phenyl)-2-chloropyrimidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C=CCCOC1=CC=CC(=C1)C2=NC(=NC=C2)Cl

Technology Process of 4-(3-(But-3-en-1-yloxy)phenyl)-2-chloropyrimidine

There total 3 articles about 4-(3-(But-3-en-1-yloxy)phenyl)-2-chloropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.3%

: 5162-44-7
1-bromo-4-butene

: 937271-43-7
3-(2-chloropyrimidine-4-yl)phenol

: 937271-45-9
4-(3-(but-3-en-1-yloxy)phenyl)-2-chloropyrimidine

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃;
DOI:10.1016/j.ejmech.2015.03.034

Reference yield:

: 3934-20-1
2,6-Dichloropyrimidine

: C₁₀H₁₃BO₃

: 937271-45-9
4-(3-(but-3-en-1-yloxy)phenyl)-2-chloropyrimidine

Guidance literature:: With palladium diacetate; In tetrahydrofuran;

Reference yield:

: 87199-18-6
3-hydroxyphenylboronic acid

: 937271-45-9
4-(3-(but-3-en-1-yloxy)phenyl)-2-chloropyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 4 h / 80 - 85 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 - 40 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; caesium carbonate; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1021/jm200326p