ethyl 7-[5-(N-3-ethynylphenylcarbamoyl)-4-hydroxy-2-methoxy-phenylamino]-7-oxoheptanoate

Base Information

Chemical Name:ethyl 7-[5-(N-3-ethynylphenylcarbamoyl)-4-hydroxy-2-methoxy-phenylamino]-7-oxoheptanoate
CAS No.:1352440-86-8
Molecular Formula:C₂₅H₂₈N₂O₆
Molecular Weight:452.507
Hs Code.:

Synonyms:ethyl 7-[5-(N-3-ethynylphenylcarbamoyl)-4-hydroxy-2-methoxy-phenylamino]-7-oxoheptanoate

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Chemical Property of ethyl 7-[5-(N-3-ethynylphenylcarbamoyl)-4-hydroxy-2-methoxy-phenylamino]-7-oxoheptanoate

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Technology Process of ethyl 7-[5-(N-3-ethynylphenylcarbamoyl)-4-hydroxy-2-methoxy-phenylamino]-7-oxoheptanoate

There total 4 articles about ethyl 7-[5-(N-3-ethynylphenylcarbamoyl)-4-hydroxy-2-methoxy-phenylamino]-7-oxoheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 14794-32-2
ethyl 6-(chloroformyl)hexanoate

: 1352440-85-7
C₁₆H₁₄N₂O₃

: 1352440-86-8
ethyl 7-[5-(N-3-ethynylphenylcarbamoyl)-4-hydroxy-2-methoxy-phenylamino]-7-oxoheptanoate

Guidance literature:: With triethylamine; In tetrahydrofuran; for 3h; Cooling with ice;
DOI:10.1016/j.bmc.2012.05.034

Reference yield:

: 1352440-84-6
N-(3-ethynylphenyl)-2-hydroxy-4-methoxy-5-nitrobenzamide

: 1352440-86-8
ethyl 7-[5-(N-3-ethynylphenylcarbamoyl)-4-hydroxy-2-methoxy-phenylamino]-7-oxoheptanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: iron; acetic acid / tetrahydrofuran; ethanol / 7 h / Reflux

1.2: pH 10 / Saturated solution

2.1: triethylamine / tetrahydrofuran / 3 h / Cooling with ice

With iron; acetic acid; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmc.2012.05.034

Reference yield:

: 2237-36-7
4-methoxysalicylic acid

: 1352440-86-8
ethyl 7-[5-(N-3-ethynylphenylcarbamoyl)-4-hydroxy-2-methoxy-phenylamino]-7-oxoheptanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: nitric acid; acetic acid / Cooling with ice

2.1: triphenyl phosphite / toluene / 8 h / Reflux

3.1: iron; acetic acid / tetrahydrofuran; ethanol / 7 h / Reflux

3.2: pH 10 / Saturated solution

4.1: triethylamine / tetrahydrofuran / 3 h / Cooling with ice

With triphenyl phosphite; nitric acid; iron; acetic acid; triethylamine; In tetrahydrofuran; ethanol; toluene;
DOI:10.1016/j.bmc.2012.05.034