N-(3-ethynylphenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido)-4-methoxybenzamide

Base Information

Chemical Name:N-(3-ethynylphenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido)-4-methoxybenzamide
CAS No.:1352440-59-5
Molecular Formula:C₂₃H₂₅N₃O₆
Molecular Weight:439.468
Hs Code.:

Synonyms:N-(3-ethynylphenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido)-4-methoxybenzamide

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Chemical Property of N-(3-ethynylphenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido)-4-methoxybenzamide

Chemical Property:

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Technology Process of N-(3-ethynylphenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido)-4-methoxybenzamide

There total 6 articles about N-(3-ethynylphenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido)-4-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1352440-86-8
ethyl 7-[5-(N-3-ethynylphenylcarbamoyl)-4-hydroxy-2-methoxy-phenylamino]-7-oxoheptanoate

: 1352440-59-5
N-(3-ethynylphenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido)-4-methoxybenzamide

Guidance literature:: With hydroxylamine hydrochloride; potassium hydroxide; In methanol; Cooling with ice;
DOI:10.1016/j.bmc.2012.05.034

Reference yield:

: 1352440-84-6
N-(3-ethynylphenyl)-2-hydroxy-4-methoxy-5-nitrobenzamide

: 1352440-59-5
N-(3-ethynylphenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido)-4-methoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: iron; acetic acid / tetrahydrofuran; ethanol / 7 h / Reflux

1.2: pH 10 / Saturated solution

2.1: triethylamine / tetrahydrofuran / 3 h / Cooling with ice

3.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / Cooling with ice

With hydroxylamine hydrochloride; iron; acetic acid; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol;
DOI:10.1016/j.bmc.2012.05.034

Reference yield:

: 2237-36-7
4-methoxysalicylic acid

: 1352440-59-5
N-(3-ethynylphenyl)-2-hydroxy-5-(7-hydroxyamino-7-oxoheptanamido)-4-methoxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: nitric acid; acetic acid / Cooling with ice

2.1: triphenyl phosphite / toluene / 8 h / Reflux

3.1: iron; acetic acid / tetrahydrofuran; ethanol / 7 h / Reflux

3.2: pH 10 / Saturated solution

4.1: triethylamine / tetrahydrofuran / 3 h / Cooling with ice

5.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / Cooling with ice

With triphenyl phosphite; hydroxylamine hydrochloride; nitric acid; iron; acetic acid; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; toluene;
DOI:10.1016/j.bmc.2012.05.034