methyl-5-((3-(benzylcarbamoyl)-6-iodo-4-oxoquinolin-1(4H)-yl)methyl)-2-methoxybenzoate

Base Information

Chemical Name:methyl-5-((3-(benzylcarbamoyl)-6-iodo-4-oxoquinolin-1(4H)-yl)methyl)-2-methoxybenzoate
CAS No.:1616491-37-2
Molecular Formula:C₂₇H₂₃IN₂O₅
Molecular Weight:582.395
Hs Code.:

Synonyms:methyl-5-((3-(benzylcarbamoyl)-6-iodo-4-oxoquinolin-1(4H)-yl)methyl)-2-methoxybenzoate

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Chemical Property of methyl-5-((3-(benzylcarbamoyl)-6-iodo-4-oxoquinolin-1(4H)-yl)methyl)-2-methoxybenzoate

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Technology Process of methyl-5-((3-(benzylcarbamoyl)-6-iodo-4-oxoquinolin-1(4H)-yl)methyl)-2-methoxybenzoate

There total 10 articles about methyl-5-((3-(benzylcarbamoyl)-6-iodo-4-oxoquinolin-1(4H)-yl)methyl)-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1616491-35-0
6-iodo-1-(4-methoxy-3-(methoxycarbonyl)benzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

: 100-46-9
benzylamine

: 1616491-37-2
methyl-5-((3-(benzylcarbamoyl)-6-iodo-4-oxoquinolin-1(4H)-yl)methyl)-2-methoxybenzoate

Guidance literature:: 6-iodo-1-(4-methoxy-3-(methoxycarbonyl)benzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 0.25h;

benzylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2014.05.028

Reference yield:

: 89-56-5
5-Methylsalicylic acid

: 1616491-37-2
methyl-5-((3-(benzylcarbamoyl)-6-iodo-4-oxoquinolin-1(4H)-yl)methyl)-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetone / Reflux

2.1: Perbenzoic acid; N-Bromosuccinimide / tetrachloromethane / Reflux

3.1: ammonia / methanol / 2 h / 70 °C

4.1: ethanol; diethyl ether / 0.25 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.67 h / 100 °C

6.1: water; hydrogenchloride / methanol / 2 h / Reflux

7.1: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 0.25 h / 20 °C

7.2: 2 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; Perbenzoic acid; ammonia; water; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmc.2014.05.028

Reference yield:

: 98165-65-2
methyl 5-(bromomethyl)-2-methoxybenzoate

: 1616491-37-2
methyl-5-((3-(benzylcarbamoyl)-6-iodo-4-oxoquinolin-1(4H)-yl)methyl)-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonia / methanol / 2 h / 70 °C

2.1: ethanol; diethyl ether / 0.25 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.67 h / 100 °C

4.1: water; hydrogenchloride / methanol / 2 h / Reflux

5.1: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 0.25 h / 20 °C

5.2: 2 h / 20 °C

With hydrogenchloride; ammonia; water; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.05.028