(tert-Butyldiphenylsiloxy)methyl 2-<(methoxymethyl)oxy>-4-methylphenyl ketone

Base Information

• Chemical Name: (tert-Butyldiphenylsiloxy)methyl 2-<(methoxymethyl)oxy>-4-methylphenyl ketone
• CAS No.: 154698-94-9
• Molecular Formula: C₂₇H₃₂O₄Si
• Molecular Weight: 448.634
• Mol file: 154698-94-9.mol

Synonyms:(tert-Butyldiphenylsiloxy)methyl 2-<(methoxymethyl)oxy>-4-methylphenyl ketone

Chemical Property of (tert-Butyldiphenylsiloxy)methyl 2-<(methoxymethyl)oxy>-4-methylphenyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (tert-Butyldiphenylsiloxy)methyl 2-<(methoxymethyl)oxy>-4-methylphenyl ketone

There total 3 articles about (tert-Butyldiphenylsiloxy)methyl 2-<(methoxymethyl)oxy>-4-methylphenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-(methoxymethoxy)-3-methylbenzene (57234-27-2) + 2-((tertbutyldiphenylsilyl)oxy)-N-methoxy-N-methylacetamide (154698-93-8) → (tert-Butyldiphenylsiloxy)methyl 2-<(methoxymethyl)oxy>-4-methylphenyl ketone (154698-94-9)

Guidance literature:

With tert.-butyl lithium; In diethyl ether; hexane; at 0 ℃; 1.) 2 h, 2.) 1 h;

DOI:10.1021/jo00080a014

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → (tert-Butyldiphenylsiloxy)methyl 2-<(methoxymethyl)oxy>-4-methylphenyl ketone (154698-94-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / imidazole, DMAP / dimethylformamide / 10 h / Ambient temperature

2: 97 percent / Me₃Al / CH₂Cl₂; hexane / 1.) -15 deg C, 30 min; room temp., 35 min, 2.) room temp., 2 h

3: 80 percent / t-BuLi / diethyl ether; hexane / 0 °C / 1.) 2 h, 2.) 1 h

With 1H-imidazole; dmap; trimethylaluminum; tert.-butyl lithium; In diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo00080a014

Reference yield:

methyl 2-((tert-butyl(diphenyl)silyl)oxy)acetate (154698-92-7) → (tert-Butyldiphenylsiloxy)methyl 2-<(methoxymethyl)oxy>-4-methylphenyl ketone (154698-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / Me₃Al / CH₂Cl₂; hexane / 1.) -15 deg C, 30 min; room temp., 35 min, 2.) room temp., 2 h

2: 80 percent / t-BuLi / diethyl ether; hexane / 0 °C / 1.) 2 h, 2.) 1 h

With trimethylaluminum; tert.-butyl lithium; In diethyl ether; hexane; dichloromethane;

DOI:10.1021/jo00080a014

upstream raw materials:

1-(methoxymethoxy)-3-methylbenzene

2-((tertbutyldiphenylsilyl)oxy)-N-methoxy-N-methylacetamide

tert-butylchlorodiphenylsilane

methyl 2-((tert-butyl(diphenyl)silyl)oxy)acetate

Downstream raw materials:

1-(tert-Butyldiphenylsiloxy)-2-cyclopropylidene-2-<2-<(methoxymethyl)oxy>-4-methylphenyl>ethane

2-Cyclopropylidene-2-(2-hydroxy-4-methylphenyl)ethanol

2-Cyclopropylidene-2-<2-<(methoxymethyl)oxy>-4-methylphenyl>ethanol

2-<2-(tert-Butyldimethylsiloxy)-4-methylphenyl>-2-cyclopropylideneethanol