4-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-2'-deoxyguanosin-3'-yl phosphate

Base Information

• Chemical Name: 4-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-2'-deoxyguanosin-3'-yl phosphate
• CAS No.: 71065-98-0
• Molecular Formula: C₄₁H₄₁ClN₅O₁₀P
• Molecular Weight: 830.231

Synonyms:4-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-2'-deoxyguanosin-3'-yl phosphate

Chemical Property of 4-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-2'-deoxyguanosin-3'-yl phosphate

Chemical Property:

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Technology Process of 4-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-2'-deoxyguanosin-3'-yl phosphate

There total 5 articles about 4-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-2'-deoxyguanosin-3'-yl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine (68892-41-1) + 4-chlorophenylphosphorodichloridate (772-79-2) → 4-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-2'-deoxyguanosin-3'-yl phosphate (71065-98-0)

Guidance literature:

With 1,2,3-triazole; triethylamine; In 1,4-dioxane; pyridine; 1.) 0 deg C, 1 h; 2.) room temp., 1 h;

DOI:10.1248/cpb.30.3951

Reference yield:

C41H41ClN5O9P → 4-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-2'-deoxyguanosin-3'-yl phosphate (71065-98-0)

Guidance literature:

C₄₁H₄₁ClN₅O₉P; With iodine; In dichloromethane; for 0.00555556h;

With water; In dichloromethane; for 0.0833333h;

Reference yield:

C35H38N5O9P (110237-99-5) → 4-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-2'-deoxyguanosin-3'-yl phosphate (71065-98-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine; diphenyl phosphorochloridate / CH₂Cl₂ / 0.25 h

2.1: I₂ / CH₂Cl₂ / 0.01 h

2.2: 0.382 g / H₂O / CH₂Cl₂ / 0.08 h

With pyridine; iodine; chlorophosphoric acid diphenyl ester; In dichloromethane;

upstream raw materials:

4-chlorophenyl phosphate

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine

4-chlorophenylphosphorodichloridate

C₃₅H₃₈N₅O₉P

Downstream raw materials:

C₆₂H₆₂ClN₁₀O₁₅P

C₄₁H₄₄ClN₁₀O₁₃P

C₅₇H₆₀Cl₂N₁₂O₂₀P₂

C₃₇H₃₉ClN₇O₁₃P

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