Acetic acid (Z)-1-acetyl-7-benzyloxy-9-(4-methoxy-phenoxymethyl)-1,2,5,6-tetrahydro-benzo[b]azocin-5-yl ester

Base Information

Chemical Name:Acetic acid (Z)-1-acetyl-7-benzyloxy-9-(4-methoxy-phenoxymethyl)-1,2,5,6-tetrahydro-benzo[b]azocin-5-yl ester
CAS No.:137964-89-7
Molecular Formula:C₃₀H₃₁NO₆
Molecular Weight:501.579
Hs Code.:

Synonyms:Acetic acid (Z)-1-acetyl-7-benzyloxy-9-(4-methoxy-phenoxymethyl)-1,2,5,6-tetrahydro-benzo[b]azocin-5-yl ester

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Chemical Property of Acetic acid (Z)-1-acetyl-7-benzyloxy-9-(4-methoxy-phenoxymethyl)-1,2,5,6-tetrahydro-benzo[b]azocin-5-yl ester

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Technology Process of Acetic acid (Z)-1-acetyl-7-benzyloxy-9-(4-methoxy-phenoxymethyl)-1,2,5,6-tetrahydro-benzo[b]azocin-5-yl ester

There total 11 articles about Acetic acid (Z)-1-acetyl-7-benzyloxy-9-(4-methoxy-phenoxymethyl)-1,2,5,6-tetrahydro-benzo[b]azocin-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137964-81-9
2-Benzylamino-6-hydroxy-4-methyl-benzoic acid ethyl ester

: 137964-89-7
Acetic acid (Z)-1-acetyl-7-benzyloxy-9-(4-methoxy-phenoxymethyl)-1,2,5,6-tetrahydro-benzo[b]azocin-5-yl ester

Guidance literature:: Multi-step reaction with 10 steps

1: H₂ / Pd/C / ethanol / 2 h / 23 °C / 62057.8 Torr

2: 1.) aq. NaNO₂, HCl, 2.) NaN₃ / 1.) EtOH, 0 deg C, 20 min, 2.) EtOH, 0 deg C, 40 min

3: i-Pr₂NEt / CH₂Cl₂ / 23 °C

4: NBS, Bz₂O₂ / benzene / 2 h / Heating

5: K₂CO₃ / dimethylformamide / 0.25 h / 70 °C

6: TFA / CH₂Cl₂ / 3 h / 23 °C

7: K₂CO₃ / dimethylformamide / 80 °C

8: 100 percent / DIBAL / CH₂Cl₂ / -78 °C

9: 98 percent / PCC / CH₂Cl₂ / 23 °C

10: toluene / 7 h / 170 °C

With hydrogenchloride; N-Bromosuccinimide; sodium azide; hydrogen; diisobutylaluminium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; trifluoroacetic acid; sodium nitrite; dibenzoyl peroxide; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/ja00027a071

Reference yield:

: 137964-84-2
2-Azido-6-benzyloxy-4-(4-methoxy-phenoxymethyl)-benzaldehyde

: 137964-89-7
Acetic acid (Z)-1-acetyl-7-benzyloxy-9-(4-methoxy-phenoxymethyl)-1,2,5,6-tetrahydro-benzo[b]azocin-5-yl ester

Guidance literature:: In toluene; at 170 ℃; for 7h; Yield given;
DOI:10.1021/ja00027a071

Reference yield:

: 100-44-7
benzyl chloride

: 137964-89-7
Acetic acid (Z)-1-acetyl-7-benzyloxy-9-(4-methoxy-phenoxymethyl)-1,2,5,6-tetrahydro-benzo[b]azocin-5-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide / 80 °C

2: 100 percent / DIBAL / CH₂Cl₂ / -78 °C

3: 98 percent / PCC / CH₂Cl₂ / 23 °C

4: toluene / 7 h / 170 °C

With diisobutylaluminium hydride; potassium carbonate; pyridinium chlorochromate; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja00027a071