13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(3-methyl-4-pyridinyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(3-methyl-4-pyridinyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester
CAS No.:1195778-00-7
Molecular Formula:C₄₁H₄₄N₄O₅
Molecular Weight:672.824
Hs Code.:

13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(3-methyl-4-pyridinyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester

Synonyms:13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(3-methyl-4-pyridinyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester

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Chemical Property of 13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(3-methyl-4-pyridinyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester

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Technology Process of 13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(3-methyl-4-pyridinyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester

There total 1 articles about 13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(3-methyl-4-pyridinyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1127234-89-2
tert-butyl 13-cyclohexyl-6-((2E,Z)-3-(dimethylamino)-2-(ethoxycarbonyl)-2-propenoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

: 1195782-30-9
4-hydrazinyl-3-methylpyridine hydrochloride

: 1195778-00-7
13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(3-methyl-4-pyridinyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: With triethylamine; In 1,4-dioxane; ethanol; at 140 ℃; for 0.666667h; Inert atmosphere; microwave;

Reference yield:

: 1195778-00-7
13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(3-methyl-4-pyridinyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester

: 1195782-32-1
13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(3-methyl-4-pyridinyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid hydrochloride

Guidance literature:: 13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(3-methyl-4-pyridinyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester; With trifluoroacetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In water; ethyl acetate;

Reference yield:

: 1195778-00-7
13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(3-methyl-4-pyridinyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester

: 13-cyclohexyl-3-methoxy-6-[4-[[(2S)-2-(methoxymethyl)-4-morpholinyl]carbonyl]-1-(3-methyl-4-pyridinyl)-1H-pyrazol-5-yl]-N-[(1-methylethyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 20 °C / Inert atmosphere

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.75 h / 20 °C / Inert atmosphere; Reflux

2.2: 17 h / 70 °C / Inert atmosphere

3.1: sodium hydroxide / tetrahydrofuran; methanol / 19 h / 20 °C / Inert atmosphere

4.1: HATU / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

4.2: 65 h / 20 °C / Inert atmosphere

With HATU; 1,1'-carbonyldiimidazole; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;