(2S)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-2-(2-thienyl)acetonitril

Base Information

Chemical Name:(2S)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-2-(2-thienyl)acetonitril
CAS No.:97036-25-4
Molecular Formula:C₁₈H₂₀N₂O₂S
Molecular Weight:328.435
Hs Code.:

Synonyms:(2S)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-2-(2-thienyl)acetonitril

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Chemical Property of (2S)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-2-(2-thienyl)acetonitril

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Technology Process of (2S)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-2-(2-thienyl)acetonitril

There total 1 articles about (2S)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-2-(2-thienyl)acetonitril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-03-3
thiophene-2-carbaldehyde

: 143-33-9,25596-52-5
sodium cyanide

: 35019-66-0
(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-amine

: 97036-27-6
(2R)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-2-(2-thienyl)acetonitril

: 97036-25-4
(2S)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-2-(2-thienyl)acetonitril

Guidance literature:: Yield given. Multistep reaction. Yields of byproduct given; 1) CH₃OH, 20 min., room temp.; 2) acetic acid, -5 degC, 2 h, -5 degC to room temp., 20 h;

Reference yield: 65.0%

: 97036-25-4
(2S)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-2-(2-thienyl)acetonitril

: 97036-29-8
(2S)-(-)-2-<(1S,2S)-(2-Hydroxy-1-hydroxymethyl-2-phenylethyl)amino>-2-(2-thienyl)essigsaeure

Guidance literature:: With hydrogenchloride; 1) -10 degC, 1 h; 2) 0 degC, 1 h; 3) room temp., 1 h; 4) 50 degC, 4 h;

Reference yield:

: 97036-25-4
(2S)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-2-(2-thienyl)acetonitril

: 4052-59-9,21124-40-3,43189-45-3,61261-51-6,65058-23-3
D-(-)-2-(2-Thienyl)-glycin

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / conc. HCl / 1) -10 degC, 1 h; 2) 0 degC, 1 h; 3) room temp., 1 h; 4) 50 degC, 4 h

2: 64 percent / periodinic acid, 2N NH₃ / H₂O / Ambient temperature

With hydrogenchloride; ammonium hydroxide; periodic acid; In water;