(2S,4S)-4-(3-Methyl-butyl)-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

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Chemical Name:(2S,4S)-4-(3-Methyl-butyl)-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester
CAS No.:204915-12-8
Molecular Formula:C₂₂H₃₃NO₄
Molecular Weight:375.508
Hs Code.:

Synonyms:(2S,4S)-4-(3-Methyl-butyl)-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

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Chemical Property of (2S,4S)-4-(3-Methyl-butyl)-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

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Technology Process of (2S,4S)-4-(3-Methyl-butyl)-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

There total 7 articles about (2S,4S)-4-(3-Methyl-butyl)-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 204915-10-6
(2S,4S)-4-(3-Methyl-butyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

: 100-51-6,185532-71-2
benzyl alcohol

: 204915-12-8
(2S,4S)-4-(3-Methyl-butyl)-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Guidance literature:: With dmap; dacarbazine; In dichloromethane; Ambient temperature;
DOI:10.1021/ja972494e

Reference yield:

: 103201-79-2,1820583-17-2
(3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

: 204915-12-8
(2S,4S)-4-(3-Methyl-butyl)-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) LDA / 1.) THF, heptane, benzene, -78 deg C, 30 min, 2.) THF, heptane, benzene, -78 deg C, 15 min

2: LAH / tetrahydrofuran / 1 h / Heating

3: H₂ / 10percent Pd/C / acetic acid; ethanol / 3 h / 3102.9 Torr

4: CH₂Cl₂

5: 1.) CrO₃, H₂SO₄, 2.) H₂ / 2.) 10percent Pd/C / 1.) acetone, 0 deg C, 1 h, 2.) acetone, 1 atm

6: 87 percent / DIC, DMAP / CH₂Cl₂ / Ambient temperature

With chromium(VI) oxide; dmap; lithium aluminium tetrahydride; sulfuric acid; hydrogen; dacarbazine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1021/ja972494e

Reference yield:

: 870-63-3
prenyl bromide

: 204915-12-8
(2S,4S)-4-(3-Methyl-butyl)-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) LDA / 1.) THF, heptane, benzene, -78 deg C, 30 min, 2.) THF, heptane, benzene, -78 deg C, 15 min

2: LAH / tetrahydrofuran / 1 h / Heating

3: H₂ / 10percent Pd/C / acetic acid; ethanol / 3 h / 3102.9 Torr

4: CH₂Cl₂

5: 1.) CrO₃, H₂SO₄, 2.) H₂ / 2.) 10percent Pd/C / 1.) acetone, 0 deg C, 1 h, 2.) acetone, 1 atm

6: 87 percent / DIC, DMAP / CH₂Cl₂ / Ambient temperature

With chromium(VI) oxide; dmap; lithium aluminium tetrahydride; sulfuric acid; hydrogen; dacarbazine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1021/ja972494e