(2S,4S)-1-[(2S,4S)-1-(2,2-Dimethyl-propionyl)-4-(3-methyl-butyl)-pyrrolidine-2-carbonyl]-4-(3-methyl-butyl)-pyrrolidine-2-carboxylic acid benzyl ester

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Chemical Name:(2S,4S)-1-[(2S,4S)-1-(2,2-Dimethyl-propionyl)-4-(3-methyl-butyl)-pyrrolidine-2-carbonyl]-4-(3-methyl-butyl)-pyrrolidine-2-carboxylic acid benzyl ester
CAS No.:204914-81-8
Molecular Formula:C₃₂H₅₀N₂O₄
Molecular Weight:526.76
Hs Code.:

Synonyms:(2S,4S)-1-[(2S,4S)-1-(2,2-Dimethyl-propionyl)-4-(3-methyl-butyl)-pyrrolidine-2-carbonyl]-4-(3-methyl-butyl)-pyrrolidine-2-carboxylic acid benzyl ester

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Chemical Property of (2S,4S)-1-[(2S,4S)-1-(2,2-Dimethyl-propionyl)-4-(3-methyl-butyl)-pyrrolidine-2-carbonyl]-4-(3-methyl-butyl)-pyrrolidine-2-carboxylic acid benzyl ester

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Technology Process of (2S,4S)-1-[(2S,4S)-1-(2,2-Dimethyl-propionyl)-4-(3-methyl-butyl)-pyrrolidine-2-carbonyl]-4-(3-methyl-butyl)-pyrrolidine-2-carboxylic acid benzyl ester

There total 11 articles about (2S,4S)-1-[(2S,4S)-1-(2,2-Dimethyl-propionyl)-4-(3-methyl-butyl)-pyrrolidine-2-carbonyl]-4-(3-methyl-butyl)-pyrrolidine-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103201-79-2,1820583-17-2
(3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

: 204914-81-8
(2S,4S)-1-[(2S,4S)-1-(2,2-Dimethyl-propionyl)-4-(3-methyl-butyl)-pyrrolidine-2-carbonyl]-4-(3-methyl-butyl)-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) LDA / 1.) THF, heptane, benzene, -78 deg C, 30 min, 2.) THF, heptane, benzene, -78 deg C, 15 min

2: LAH / tetrahydrofuran / 1 h / Heating

3: H₂ / 10percent Pd/C / acetic acid; ethanol / 3 h / 3102.9 Torr

4: CH₂Cl₂

5: 1.) CrO₃, H₂SO₄, 2.) H₂ / 2.) 10percent Pd/C / 1.) acetone, 0 deg C, 1 h, 2.) acetone, 1 atm

6: DIC, HOBt, DMAP, Et₃N / CH₂Cl₂

7: HCl, AcOH / 1 h / Ambient temperature

8: Et₃N / CH₂Cl₂ / 0.25 h

With chromium(VI) oxide; hydrogenchloride; dmap; lithium aluminium tetrahydride; sulfuric acid; hydrogen; benzotriazol-1-ol; acetic acid; dacarbazine; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1021/ja972494e

Reference yield:

: [(2S,4S)-1-Benzyl-4-(3-methyl-but-2-enyl)-pyrrolidin-2-yl]-methanol

: 204914-81-8
(2S,4S)-1-[(2S,4S)-1-(2,2-Dimethyl-propionyl)-4-(3-methyl-butyl)-pyrrolidine-2-carbonyl]-4-(3-methyl-butyl)-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / 10percent Pd/C / acetic acid; ethanol / 3 h / 3102.9 Torr

2: CH₂Cl₂

3: 1.) CrO₃, H₂SO₄, 2.) H₂ / 2.) 10percent Pd/C / 1.) acetone, 0 deg C, 1 h, 2.) acetone, 1 atm

4: DIC, HOBt, DMAP, Et₃N / CH₂Cl₂

5: HCl, AcOH / 1 h / Ambient temperature

6: Et₃N / CH₂Cl₂ / 0.25 h

With chromium(VI) oxide; hydrogenchloride; dmap; sulfuric acid; hydrogen; benzotriazol-1-ol; acetic acid; dacarbazine; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid;
DOI:10.1021/ja972494e

Reference yield:

: 870-63-3
prenyl bromide

: 204914-81-8
(2S,4S)-1-[(2S,4S)-1-(2,2-Dimethyl-propionyl)-4-(3-methyl-butyl)-pyrrolidine-2-carbonyl]-4-(3-methyl-butyl)-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) LDA / 1.) THF, heptane, benzene, -78 deg C, 30 min, 2.) THF, heptane, benzene, -78 deg C, 15 min

2: LAH / tetrahydrofuran / 1 h / Heating

3: H₂ / 10percent Pd/C / acetic acid; ethanol / 3 h / 3102.9 Torr

4: CH₂Cl₂

5: 1.) CrO₃, H₂SO₄, 2.) H₂ / 2.) 10percent Pd/C / 1.) acetone, 0 deg C, 1 h, 2.) acetone, 1 atm

6: DIC, HOBt, DMAP, Et₃N / CH₂Cl₂

7: HCl, AcOH / 1 h / Ambient temperature

8: Et₃N / CH₂Cl₂ / 0.25 h

With chromium(VI) oxide; hydrogenchloride; dmap; lithium aluminium tetrahydride; sulfuric acid; hydrogen; benzotriazol-1-ol; acetic acid; dacarbazine; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1021/ja972494e