5-[[(3-bromo-2-methoxypyridin-4-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

Base Information

Chemical Name:5-[[(3-bromo-2-methoxypyridin-4-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS No.:952138-16-8
Molecular Formula:C₁₃H₁₃BrN₂O₅
Molecular Weight:357.161
Hs Code.:

Synonyms:5-[[(3-bromo-2-methoxypyridin-4-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

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Chemical Property of 5-[[(3-bromo-2-methoxypyridin-4-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

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Technology Process of 5-[[(3-bromo-2-methoxypyridin-4-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

There total 1 articles about 5-[[(3-bromo-2-methoxypyridin-4-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 215364-86-6
3-bromo-2-methoxypyridin-4-ylamine

: 15568-85-1
5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione

: 952138-16-8
5-[[(3-bromo-2-methoxypyridin-4-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

Guidance literature:: In isopropyl alcohol; Heating;
DOI:10.1016/j.tet.2008.01.055

Reference yield: 96.0%

: 952138-16-8
5-[[(3-bromo-2-methoxypyridin-4-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

: 952138-17-9
8-bromo-7-methoxy-1,4-dihydro-1,6-naphthyridin-4-one

Guidance literature:: In diphenylether; at 220 ℃; for 1h;

Reference yield:

: 952138-16-8
5-[[(3-bromo-2-methoxypyridin-4-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

: C₂₃H₂₃N₅O₄

Guidance literature:: Multi-step reaction with 6 steps

1: diphenylether; biphenyl / 0.08 h / 120 - 250 °C

2: ammonium formate / 5% palladium over charcoal / methanol / 4 h / Heating / reflux

3: N-ethyl-N,N-diisopropylamine; trichlorophosphate / para-dichlorobenzene / 1.5 h / 10 - 70 °C

4: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 70 °C

5: trifluoroacetic acid / dichloromethane / 1 h / 45 °C

6: N-[(6-chlorobenzotriazol-1-yl)oxy-(dimethylamino)methylene]-dimethyl-ammonium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

With N-[(6-chlorobenzotriazol-1-yl)oxy-(dimethylamino)methylene]-dimethyl-ammonium tetrafluoroborate; ammonium formate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; 5% palladium over charcoal; In methanol; diphenylether; biphenyl; para-dichlorobenzene; dichloromethane; N,N-dimethyl-formamide;