952138-17-9

Usage

Uses

Used in Pharmaceutical Development:
8-Bromo-7-Methoxy-1,6-naphthyridin-4(1H)-one is used as a potential pharmaceutical agent for its antimicrobial properties. The presence of the 8-bromo and 7-methoxy groups may enhance its activity against certain pathogens, making it a candidate for further investigation in the development of new antimicrobial drugs.
Used in Antimicrobial Applications:
In the field of antimicrobial research, 8-Bromo-7-Methoxy-1,6-naphthyridin-4(1H)-one is used as a compound with potential antimicrobial activity. Its structure, including the naphthyridin-4-one core and the substituents, suggests that it could be effective against a range of microorganisms, warranting further study to determine its efficacy and safety in clinical settings.
Used in Biochemical Research:
8-Bromo-7-Methoxy-1,6-naphthyridin-4(1H)-one is used as a research tool in biochemical studies. Its unique structure allows scientists to explore its interactions with biological molecules, which could lead to a better understanding of its potential therapeutic applications and mechanisms of action.

Upstream product

• 20265-39-8 4-amino-2-methoxypyridine 
• 215364-86-6 3-bromo-2-methoxypyridin-4-ylamine 
• 14432-12-3 4-Amino-2-chloropyridine 
• 215364-85-5 3-bromo-2-chloro-pyridin-4-ylamine 
• 952138-16-8 5-[[(3-bromo-2-methoxypyridin-4-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione 

Downstream Products

• 952138-18-0 7-methoxy-1,4-dihydro-1,6-naphthyridin-4-one 
• 952138-20-4 tert-butyl 2-[2-methoxy-4-(7-methoxy-1,6-naphthyridin-4-yloxy)phenyl]acetate 
• 952138-15-7 2-[2-methoxy-4-(7-methoxy-1,6-naphthyridin-4-yloxy)phenyl]acetic acid 
• 952138-19-1 4-chloro-7-methoxy-[1,6]naphthyridine 

Relevant academic research and scientific papers

PYRIDO-AZAHETERECYDIC COMPOUND AND PREPARATION METHOD AND USE THEREOF

The present invention discloses a pyrido-azacyclic compound represented by formula I, an isomer thereof, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof, a preparation process thereof and a composition comprising the compound, and a use thereof as a multi-target protein kinase inhibitor in the preparation of a medicament for the treatment of diseases that are associated with protein kinase, especially c-Met, such as cancer and the like. The compound represented by formula I has potent inhibitory activity on tumor cells with overexpression of c-Met kinase, can effectively target c-Met-mediated signaling pathway, and can be used in the treatment of diseases such as cancer and the like that is caused by the overexpression of c-Met kinase.

Aurora Kinase Modulators and Method of Use

The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

AURORA KINASE MODULATORS AND METHOD OF USE

The present invention relates to chemical compounds having a general formula I {INSERT STRUCTURE HERE} wherein A1-8, D,, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

Strategic studies in the syntheses of novel 6,7-substituted quinolones and 7- or 6-substituted 1,6- and 1,7-naphthyridones

This paper describes the different strategies devised and applied to overcome the selectivity issues in the syntheses of 6,7-disubstituted-1H-quinolin-4-one, 7-substituted-1H-1,6-naphthyridin-4-one and 6-substituted-1H-1,7-naphthyridin-4-one derivatives. They allowed us to improve the overall yields and the scaling-up feasibility. Several examples illustrate these strategies with their advantages and drawbacks.

FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

NAPHTHYRIDINE DERIVATIVES AS ANTI-CANCER AGENTS

The invention concerns naphthyridine derivatives of Formula (I): or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, G1, G2, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders or disease states associated with angiogenesis and/or vascular permeability.