(RS,SS)-2-Methyl-3-phenyl-1-<2-(1-methoxy-1-methylethyl)pyrrolidin-1-yl>propan-1-on

Base Information

• Chemical Name: (RS,SS)-2-Methyl-3-phenyl-1-<2-(1-methoxy-1-methylethyl)pyrrolidin-1-yl>propan-1-on
• CAS No.: 484689-80-7
• Molecular Formula: C₁₈H₂₇NO₂
• Molecular Weight: 289.418
• Mol file: 484689-80-7.mol

Synonyms:(RS,SS)-2-Methyl-3-phenyl-1-<2-(1-methoxy-1-methylethyl)pyrrolidin-1-yl>propan-1-on

Chemical Property of (RS,SS)-2-Methyl-3-phenyl-1-<2-(1-methoxy-1-methylethyl)pyrrolidin-1-yl>propan-1-on

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (RS,SS)-2-Methyl-3-phenyl-1-<2-(1-methoxy-1-methylethyl)pyrrolidin-1-yl>propan-1-on

There total 3 articles about (RS,SS)-2-Methyl-3-phenyl-1-<2-(1-methoxy-1-methylethyl)pyrrolidin-1-yl>propan-1-on which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-(-)-2-(1-methoxy-1-methylethyl)-pyrrolidine (118971-00-9,160142-25-6) + 2-methyl-3-phenylpropanoyl chloride (81136-08-5,81136-06-3,81136-09-6,38385-67-0) → (RS,SS)-2-Methyl-3-phenyl-1-<2-(1-methoxy-1-methylethyl)pyrrolidin-1-yl>propan-1-on (484689-80-7)

Guidance literature:

With triethylamine; In ethyl acetate; for 3h; Ambient temperature;

DOI:10.1002/hlca.19950780416

Reference yield: 75.0%

benzyl bromide (100-39-0) + 1-[(S)-(-)-2-(2-methoxypropan-2-yl)pyrrolidin-1-yl]propan-1-one (184883-01-0) → (RS,SS)-2-Methyl-3-phenyl-1-<2-(1-methoxy-1-methylethyl)pyrrolidin-1-yl>propan-1-on (484689-80-7)

Guidance literature:

With lithium perchlorate; lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1002/1522-2675(200207)85:7<2073::AID-HLCA2073>3.0.CO;2-1

Reference yield:

(S)-(-)-2-(1-methoxy-1-methylethyl)-pyrrolidine (118971-00-9,160142-25-6) → (RS,SS)-2-Methyl-3-phenyl-1-<2-(1-methoxy-1-methylethyl)pyrrolidin-1-yl>propan-1-on (484689-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / Et₃N / ethyl acetate / 0.5 h / 5 °C

2: 75 percent / LDA; LiClO₄ / tetrahydrofuran / -78 - 20 °C

With lithium perchlorate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; ethyl acetate;

DOI:10.1002/1522-2675(200207)85:7<2073::AID-HLCA2073>3.0.CO;2-1

upstream raw materials:

(S)-(-)-2-(1-methoxy-1-methylethyl)-pyrrolidine

2-methyl-3-phenylpropanoyl chloride

benzyl bromide

1-[(S)-(-)-2-(2-methoxypropan-2-yl)pyrrolidin-1-yl]propan-1-one

Downstream raw materials:

(R)-4-benzyl-4-methyl-2-phenyl-1,3-thiazole-5(4H)-thione

(S)-4-benzyl-4-methyl-2-phenyl-1,3-thiazole-5(4H)-thione

N-<(S)-1-Benzyl-1-methyl-2-<(S)-2-(1-methoxy-1-methylethyl)pyrrolidin-1-yl>-2-thioxoethyl>benzamid

N-<(R)-1-Benzyl-1-methyl-2-<(S)-2-(1-methoxy-1-methylethyl)pyrrolidin-1-yl>-2-thioxoethyl>benzamid