2-methyl-5-benzylsulfonylamino-6-oxo-1,6-dihydro-1-pyrimidinylacetyl-Ng-nitro-L-argininal ethyl cyclol

Base Information

Chemical Name:2-methyl-5-benzylsulfonylamino-6-oxo-1,6-dihydro-1-pyrimidinylacetyl-Ng-nitro-L-argininal ethyl cyclol
CAS No.:193278-25-0
Molecular Formula:C₂₂H₃₀N₈O₇S
Molecular Weight:550.596
Hs Code.:

Synonyms:2-methyl-5-benzylsulfonylamino-6-oxo-1,6-dihydro-1-pyrimidinylacetyl-Ng-nitro-L-argininal ethyl cyclol

Suppliers and Price of 2-methyl-5-benzylsulfonylamino-6-oxo-1,6-dihydro-1-pyrimidinylacetyl-Ng-nitro-L-argininal ethyl cyclol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-methyl-5-benzylsulfonylamino-6-oxo-1,6-dihydro-1-pyrimidinylacetyl-Ng-nitro-L-argininal ethyl cyclol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-methyl-5-benzylsulfonylamino-6-oxo-1,6-dihydro-1-pyrimidinylacetyl-Ng-nitro-L-argininal ethyl cyclol

There total 9 articles about 2-methyl-5-benzylsulfonylamino-6-oxo-1,6-dihydro-1-pyrimidinylacetyl-Ng-nitro-L-argininal ethyl cyclol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 180250-77-5
Ng-nitroargininal ethyl cyclol hydrochloride

: 179523-84-3
2-methyl-5-benzylsulfonylamino-6-oxo-1 6-dihydro-1-pyrimidinylacetic acid

: 193278-25-0
2-methyl-5-benzylsulfonylamino-6-oxo-1,6-dihydro-1-pyrimidinylacetyl-Ng-nitro-L-argininal ethyl cyclol

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In acetonitrile;
DOI:10.1016/S0960-894X(97)00258-8

Reference yield:

: 53135-24-3
ethyl 3,4-dihydro-4-oxo-2-methylpyrimidine-5-carboxylate

: 193278-25-0
2-methyl-5-benzylsulfonylamino-6-oxo-1,6-dihydro-1-pyrimidinylacetyl-Ng-nitro-L-argininal ethyl cyclol

Guidance literature:: Multi-step reaction with 7 steps

1: 45 percent / TBAF / 1,2-dimethoxy-ethane

2: 67 percent / LiOH

3: 1.) DPPA, Et₃N / 1.) dioxane, 110 deg C, 2.) 110 deg C

4: 100 percent / H₂ / Pd/C / ethanol

5: 82 percent / NMM, K₂CO₃ / methanol; H₂O

6: 76 percent / CF₃COOH / CH₂Cl₂

7: 71 percent / EDC, HOBt, NMM / acetonitrile

With 4-methyl-morpholine; lithium hydroxide; diphenyl-phosphinic acid; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/S0960-894X(97)00258-8

Reference yield:

: 179524-41-5
3-(t-butyl acetyl)-2-methyl-pyrimidin-6(1H)-one-5-carboxylic acid

: 193278-25-0
2-methyl-5-benzylsulfonylamino-6-oxo-1,6-dihydro-1-pyrimidinylacetyl-Ng-nitro-L-argininal ethyl cyclol

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) DPPA, Et₃N / 1.) dioxane, 110 deg C, 2.) 110 deg C

2: 100 percent / H₂ / Pd/C / ethanol

3: 82 percent / NMM, K₂CO₃ / methanol; H₂O

4: 76 percent / CF₃COOH / CH₂Cl₂

5: 71 percent / EDC, HOBt, NMM / acetonitrile

With 4-methyl-morpholine; diphenyl-phosphinic acid; hydrogen; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/S0960-894X(97)00258-8